氟比洛芬酯超前镇痛对腹腔镜下直肠癌根治术患者术后镇痛的影响

Effect of analgesic of flurbiprofen axetil pre-emptive analgesia in laparoscopic assisted radical resection for rectal cancer

目的探讨氟比洛芬酯超前镇痛对腹腔镜下直肠癌根治术患者术后镇痛效果的影响。方法将60例拟行腹腔镜下直肠癌根治术患者随机分为两组,各30例。观察组麻醉诱导前给予氟比洛芬酯100 mg,静脉注射;对照组术后给予氟比洛芬酯100 mg,静脉注射。观察两组患者术后不同时间段疼痛视觉模拟评分(VAS)、舒适度评分(BCS)及术后炎症细胞因子水平变化和不良反应情况。结果观察组术后4 h、8 h时VAS评分均低于对照组(P<0.01);观察组术后2 h、4 h、8 h时BCS评分均高于对照组(P<0.01);观察组术后白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)水平均低于对照组(P<0.01);两组术后不良反应发生率差异无统计学意义(P>0.05)。结论氟比洛芬酯超前镇痛对腹腔镜下直肠癌根治术患者术后镇痛效果显著,可提高患者舒适度,减轻术后炎性反应。

Objective To study effect of analgesic of flurbiprofen axetil pre-emptive analgesia in laparoscopic assisted radical resection for rectal cancer. Methods Sixty patients undergoing laparoscopic radical resection for rectal cancer were divided into two groups（ n = 30 each）. The observation group before anesthesia induction received an injection flurbiprofen axetil 100 mg and the control group was given postoperatively injection flurbiprofen axetil 100 mg. VAS score,BCS scores,inflammatory cytokine levels and adverse reaction between the two groups were observed and compared. Result VAS score,IL-2,IL-6,TNF alpha level of the observation group at postoperative 4th and 8th h were lower than that of the control group（ P〈0. 01） but BCS score at postoperative 2nd h,4th and 8th h was higher than that of control group（ P〈0. 01） and postoperative IL-2,Il-6 and α（ TNF-α） were lower than that of the control group（ P〈0. 01） and there was no significant difference between postoperative adverse reaction rates of the two groups（ P〉0. 05）. Conclusion Flurbiprofen axetil pre-emptive analgesia can obviously improve analgesia effect of laparoscopic assisted radical resection for rectal cancer and improve degree of comfort and reduce inflammatory reaction of the patients.