碘氟醇在冠心病伴轻度慢性肾功能不全患者中的应用

Application of ioversol in mild chronic renal insufficiency patients with coronary heart disease

目的比较碘氟醇与碘克沙醇在冠心病伴轻度慢性肾功能不全患者介入术后对肾功能的影响,并探讨碘氟醇应用的安全性。方法选择冠心病伴轻度肾功能不全[即肾小球滤过率（GFR）介于60~90ml/1.73m2·min]的患者60例,根据冠状动脉介入诊疗应用造影剂的不同,随机分为等渗组（n=30,应用碘克沙醇）和低渗组（n=30,应用碘氟醇）,比较两组介入治疗后肾小球虑过率（GFR）的差异。结果两组患者年龄、肾功能、血红蛋白及术中造影剂用量无差异（P〉0.05）,术后24小时及3、7天的肾小球滤过率也无统计学差异（P〉0.05）。结论碘氟醇在冠心病伴轻度慢性肾功能不全患者中的应用是安全的,造影效果与碘克沙醇无明显差异,但价格便宜,可在临床推广应用。

Objective To compare effect of ioversol and iodixanol on renal function after intervention operation in mild chronic renal insufficiency patients with coronary heart disease and explore the safety of ioversol application in the patients.Methods 60 coronary heart disease patients with mild renal insufficiency（GFR between 60-90 ml/min 1.73m2）were randomly divided into isotonic group treated with iodixanol（n=30）and low permeability group treated with ioversol（n=30）.GFR after intervention operation was observed.Results The age,renal function,hemoglobin and contrast agent dosage of the two groups had no difference.The GFR of the two groups after 24 hours,3days,7days of the intervention operation had no statistical difference（P〉0.05）.Conclusion Application of ioversol in mild chronic renal insufficiency patients with coronary heart disease is safe and cheaper which has the same imaging effect as iodixanol.