摘要
冠心病已成为全球死亡率最高的疾病之一,严重威胁着人类的健康。由于冠心病的高发病率及高死亡率,对其病因研究显得十分重要。除了传统的危险因素之外,高同型半管氨酸血症被认为是冠心病新的独立危险因素,而其代谢酶MTHFR基因的多态性是否和冠心病相关还没有一个统一的结论。本文就同型半管氨酸(Hcy)及其代谢关键酶MTHFR基因多态性与冠心病的相关性研究进展作一综述。
Coronary artery disease has became one of the highest mortality disease and seriously threat to human health.Due to the high incidence of coronary heart disease and high mortality,it is very important to study the cause.In addition to traditional risk factors,Hyperhomocysteinaemia(HCA)is regarded as a new independent risk factor of coronary artery disease,but MTHFR gene polymorphism association with coronary artery disease(CAD)is not clear.The purpose of this article is to summarize the influence of homocysteine and MTHFR gene polymorphism in the coronary artery disease.
出处
《西部医学》
2015年第3期478-480,F0003,共4页
Medical Journal of West China
基金
南充市应用技术研究与开发项目(12A0040)