原发性肝癌患者体质类型与复发关系的Cox回归分析

Cox Regression Analysis of Relationship between Body Constitution and Recurrence in Patients with Primary Liver Carcinoma

目的探讨原发性肝癌患者复发的危险因素及与中医体质的关系,为预测和预防肝癌的复发提供依据。方法总结2009年1—12月上海长海医院中医科、介入科收治的109例原发性肝癌术后患者的临床特征,并分析其中医体质分布规律。用单因素及多因素Cox回归分析原发性肝癌术后复发的相关影响因素。结果 Cox回归分析结果显示,截至2010年4月1日,原发性肝癌术后出现复发患者的年龄、临床分期、肝功能分级、既往饮酒史与未出现复发患者相比较,差异具有统计学意义(P<0.05)。年龄、临床分期、乙型病毒性肝炎病史、阳虚质、血瘀质进行入Cox回归模型。结论年龄、临床分期、乙型病毒性肝炎病史、既往饮酒史是原发性肝癌术后复发的危险因素,阳虚质、血瘀质得分越高的患者,术后出现复发的时间越短。

Objective To explore the relationship between traditional Chinese medicine（TCM）body constitution and recurrence in patients with primary liver carcinoma（PLC）,in order to provide a basis for the prediction and prevention of liver recurrence.Methods The clinical characteristics of 109 surgically treated patients with PLC,who were admitted to the Department of TCM and the Department of Interventional Therapy in our hospital from January to December,2009,were summarized.The types of their TCM body constitution were analyzed.The relevant factors influencing postoperative recurrence of PLC were subjected to univariate and multivariate Cox regression analysis.Results According to the results of Cox regression analysis up to April 1,2010,there were significant differences in age,clinical stage,classification of liver function,and history of drinking between patients with and without postoperative recurrence of PLC（P〈0.05）.Age,clinical stage,history of hepatitis B,Yang deficiency constitution and blood stasis constitution entered into the Cox regression model.Conclusion Age,clinical stage,history of hepatitis B,and history of drinking are risk factors for postoperative recurrence of PLC.The higher scores of yang deficiency constitution and blood stasis constitution patients have,the sooner PLC recurs after surgery.