结肠癌与PINCH和环氧合酶2蛋白的相关性

Correlation of colon cancer and PINCH and COX-2 protein

目的研究结肠癌与PINCH(particulary interesting new cysteinehistidine rich protein)与环氧合酶2(cyclooxygenase 2,COX-2)蛋白的相关性。方法选取2012年1月至2014年9月间收治的80例结肠癌患者为研究组,另选取同期30例结肠正常者为对照组,采用免疫组织化Envision法检测两组的PINCH和COX-2蛋白表达情况,并分析其表达与结肠癌生物学行为的相关性。结果研究组患者PINCH和COX-2的表达均高于对照组,差异有统计学意义(P<0.05)。PINCH表达与结肠癌淋巴结转移、远处转移和浸润深度相关(P<0.05);COX-2表达与结肠癌Dukes分期、肿瘤直径、淋巴结转移及远处转移、浸润深度相关(P<0.05)。PINCH与COX-2在结肠癌组织中的表达呈正相关(r=0.520,P<0.04)。结论 PINCH、COX-2蛋白表达异常可能预示着结肠癌发生,二者相互协同,在结肠癌浸润、转移过程中发挥作用。

Objective To explore the correlation of colon cancer and particulary interesting new cysteinehistidine rich protein（ PINCH） and cyclooxygenase 2（ COX-2） protein. Methods From January2012 to September 2014 in Gucheng County Hospital,80 colon cancer patients were admitted in the study as research group,and in the same period 30 cases of normal colon were enrolled as control group. PINCH and COX-2 protein expressions were detected using immunohistochemical Envision method. The expressions and correlation between colon cancer biology were analyzed. Results The PINCH and COX-2 expressions were higher than those of the control group（ P〈0. 05）. PINCH expression was related to colon cancer with lymph node metastasis and distant metastases,infiltrating depth（ P〈0. 05）; COX-2 expression was related to Dukes staging of colon cancer,tumor diameter,whether with lymph node metastasis and distant metastases,infiltrating depth（ P〈0. 05）. PINCH and COX-2 expression in colon cancer patients exhibited positive correlation（ r = 0. 520,P〈0. 04）. Conclusions PINCH,COX-2 protein abnormalities may indicate colon cancer and they could produce certain effect in the process of colon cancer invasion and metastasis.