子痫前期患者外周血中Th_1、Th_2、Th_1/Th_2比率与hs-CRP变化及其临床意义

The clinical indication of cell count of Th1 and Th2,ratio of Th1/Th2 and the variation of hs-CRP from peripheral blood in patients with preeclampsia

目的观察子痫前期患者外周血中辅助性T淋巴细胞1(Th1)、辅助性T淋巴细胞2(Th2)、Th1/Th2比率与超敏C反应蛋白(hs-CRP)水平的变化,探讨其变化与子痫前期发生、发展的关系。方法采用流式细胞技术检测63例子痫前期患者(轻度35例,重度28例)和45例正常妊娠孕妇外周血中Th1、Th2、Th1/Th2比率,同时检测其hs-CRP水平。结果 1子痫前期组Th1、Th1/Th2比率、hs-CRP水平均高于正常妊娠组(P<0.05),其中重度组Th1、Th1/Th2比率、hs-CRP水平明显高于轻度组(P<0.01)。2Th1/Th2比率与hs-CRP呈正相关(r=0.72,P=0.025),且随病情的严重程度呈上升趋势。结论子痫前期患者体内Th1/Th2比率处于失衡状态,联合检测Th1/Th2比率与hs-CRP水平,可用于评价子痫前期病情的严重程度。

Objective：To observe the various levels of T-helper1（Th1）and T-helper-2（Th2）cell counts,Th1 to Th2 ratio and the changes of high sensitivity C reaction-protein further to discuss those changes associated with development and progression of preeclampsia. Methods：Use flow-cytometry technology to determine the Th1 and Th2 cell number,Th1 to Th2 ratio and the hs-CRP level from the peripheral blood of 63 patients with preeclampsia and 45 normal pregnant women. Results：（1）The Th1 number,Th1 to Th2 ratio and hs-CRP level are higher in preeclampsia groups compared with normal pregnant women.（P〈0.05）And the Th1 number,ratio of Th1 to Th2 and hs-CRP level are higher in severe group than in mild group（P〈0.01）（2）The ratio of Th1 to Th2 is positively correlated with hs-CRP（r=0.72,P=0.025）and is fluctuating upward trend with the severity of illness. Conclusions：Due to Th1 to Th2 ratio disorder of patients with preeclampsia,it is feasible to evaluate the severity of preeclampsia by joint detection of Th1 to Th2 ratio and hs-CRP level.