脐血及羊水联合检测在新生儿早发型败血症诊断中的临床应用

The clinical application of umbilical blood and amniotic fluid joint detection to the diagnosis of early-onset infection in neonates

随着围产医学的发展,危重新生儿尤其是早产儿及极低出生体重儿的存活率明显上升。由于新生儿免疫功能尚未发育成熟等原因,感染仍然是目前面临的重要问题,并对新生儿预后造成严重危害。由于新生儿的高感染易感性以及新生儿感染时临床症状的不典型性和多样性,使得早期诊治成为改善患儿预后的关键。脐血及羊水检测具有早期、无创伤、安全、方便的优点。该文主要探讨脐血及羊水炎性标志物联合检测在新生儿早发型败血症中的临床应用。

Continuing advances in Perinatology have contributed to the obviously increased survival of premature and low gestational age neonates. Because of the neonatal immune system is immature,infection is still an important issue and severely impair the newborns outcomes. Due to the high susceptibility to infection,atypical and diversity clinical symptoms,early diagnosis and therapy are the key to improve the prognosis of sick children. Umbilical blood and amniotic fluid detection is very early,noninvasive,safe and convenient. We mainly discuss the clinical application of inflammatory biomarkers in umbilical blood and amniotic fluid joint detection to the diagnosis of early-onset infection in neonates.