Eudragit NE30D膜的制备及其性能参数的标准化研究

Preparation of Eudragit NE30D films and standardizing its properties parameter

目的考察Eudragit NE30D膜的制备条件,探索膜性能参数的标准化方法。方法分别使用质量分数5%、7.5%、10%、12.5%、15%的Eudragit NE30D水分散液,考察了1、2 mL两种体积和25、40、55℃温度对Eudragit NE30D膜制备的影响,比较了其厚度、均匀度、表面平滑度、含水量、透湿量、抗张强度、断裂伸长率。结果 Eudragit NE30D适宜的成膜温度为40℃,成膜时间4～6 h,操作体积为1 mL,质量分数为5%～10%,控制含水量5%。制得的膜标准化参数、透湿性和机械性能的重现性良好。结论本法简单可行,为研究Eudragit NE30D性能提供参考。

Objective To optimize preparation of Eudragit NE30D films, and explore the standardized method of its parameter properties. Methods Preparation of Eudragit NE30D films was optimized on four concentrations（5%, 7.5%, 10%, 12.5%, and 15%） of Eudragit NE30D aqueous dispersion with two kinds of volume（1 mL and 2 mL） and three kinds of temperature（25, 40, and 55 ℃）, and the thickness, evenness, smoothness, water content, moisture permeability, tensile strength, and breaking longation of NE30D membranes were determined. Results The optimum conditions of Eudragit NE30 D films were as following： temperature of forming films was 40 ℃, the film forming time was 4 — 6 h, the operation volume was 1 mL, the concentrationwas 5% — 10%, and the water contentwas 5%. Eudragit NE30D films had good reproducibility on standardized parameters, moisture permeability, and mechanical property. Conclusion The method of forming films is simple and feasible which provides reference for further study of Eudragit NE30D.