妊娠高血压综合征孕妇晚期血清尿酸值检测在围产儿预后判断中的意义

Pregnancy Induced Hypertension in Late Trimester of Pregnancy Serum uric Acid Detection in the Perinatal Prognosis

目的：分析妊娠高血压综合征（妊高征）孕妇晚期血清尿酸值检测在围产儿预后判断中的意义。方法：选取2011年3月-2013年6月间在我院进行治疗的晚期妊高征孕妇100例为研究对象进行分析,另选取同期健康产妇50例为对照组,所有参与研究者均检测血血清尿酸,对比不同时间段两组患者血清尿酸值,分析尿酸值变化与患者病情关系,对比两组患者围产儿产儿预后情况。结果：两组患者不同时间段血清尿酸值均有显著差异,研究组明显较高,差异具有统计学意义（P〈0.05）;尿酸升高组患者24h尿蛋白定量、眼底异常发生率显著高于正常组,差异具有统计学意义（P〈0.05）,肝功能异常、心电图异常和肾功能其他指标、HELLP综合征、胎盘早剥、眼底出血、心力衰竭、肾功能衰竭对比差异无统计学意义（P〉0.05）;妊高征晚期患者轻度、中度、重度围产儿预后不良发生率对比差异具有统计学意义（P〈0.05）,研究组患者围产儿预后不良发生率为57%,尿酸正常组为34%,尿酸升高组为80%,对比差异具有统计学意义（P〈0.05）,相关性分析结果显示,尿酸升高与围产儿预后不良发生率呈正相关,说明尿酸值检测对指示围产儿预后有重要参考价值。结论：妊高征孕妇血清尿酸升高与围产儿预后密切相关,加强对尿酸变化监测对围产儿预后分析有重要指导意义。

Objective： To analyze the pregnancy induced hypertension in late trimester of pregnancy serum uric acid was detected in the perinatal prognosis.Methods：From 2011 March to 2013 June in our hospital for treatment of 100 cases of pregnant women in late pregnancy induced hypertension are studied,the other 50 healthy women were selected as control group,all the participants were detected in blood serum uric acid in different period of time,two groups of patients with serum uric acid,uric acid analysis change and patient relationship,perinatal fetal prognosis of patients in two groups of contrast around.Results：There was a significant difference between the two groups of patients with different time of serum uric acid values,the study group was significantly higher,the differences were statistically significant（P〈0.05）;Elevated uric acid group,24 h urine protein in patients with fundus abnormalities were significantly higher than that in the normal group,the difference was statistically significant（ P〈0.05）,abnormal liver function,ECG abnormality renal function and other indicators,HELLP syndrome,placental abruption,fundus hemorrhage,renal failure,heart failure compared no significant difference（P〉0.05）;pregnancy in patients with mild,moderate,and high in late stage of severe adverse perinatal outcome incidence compared the difference was statistically significant（P〈0.05）,the study group patients perinatal prognosis occurrence rate is 57%,the normal uric acid group was 34%,elevated uric acid group was 80%,statistically significant differences（P〈0.05）,the correlation analysis showed that urinary acid with increased incidence of adverse perinatal outcome were positively correlated,indicating that uric acid detection on perinatal prognosis have important reference value.Conclusion：The increase of PIH pregnant women serum uric acid is closely related with the prognosis of perinatal fetus,strengthen has an important guiding significance to the uric acid change monitoring analysis on perinatal outcome.