超敏C反应蛋白与糖类抗原125检测对子宫内膜癌的诊断价值及预后的相关性研究

Correlation study on diagnostic value and prognosis of high-sensitivity C-reactive protein and carbohydrate antigen 125 for endometrial cancer

目的:探讨超敏C反应蛋白与糖类抗原125检测对子宫内膜癌的诊断价值及预后的相关性。方法:选择2012年6月至2014年6月我院接诊的50例子宫内膜癌患者进行研究,将其作为观察组。对照组选取50例正常患者。回顾性分析与比较两组患者的超敏C反应蛋白与糖类抗原125的含量以及阳性率。结果:术前,观察组的超敏C反应蛋白的含量多于对照组,二者相比有统计学差异(t=9.8663,P<0.0001);观察组术前的糖类抗原125的含量多于对照组,二者相比有统计学差异(t=6.9395,P<0.0001);观察组与对照组的超敏C反应蛋白阳性分别为56.00%与0.00%,二者相比有统计学差异(χ2=38.8889,P<0.0001);观察组的糖类抗原125阳性、超敏C反应蛋白与糖类抗原125阳性比例均高于对照组(P<0.05)。术后,观察组的超敏C反应蛋白的比例、超敏C反应蛋白与糖类抗原125阳性的比例与对照组相比无统计学差异(P>0.05)。结论:超敏C反应蛋白与糖类抗原125检测对子宫内膜癌具有较高的诊断价值,并能对患者的预后提供参考。

Objectives： To investigate the correlation of high-sensitivity C-reactive protein and carbohydrate antigen 125 on the diagnostic value and prognosis of endometrial cancer. Methods： 50 patients with endometrial cancer from June 2012 to June 2014 in our hospital were researched and regarded as observation groups. Control group were 50 normal people. The content and positive rates of C-reactive protein and carbohydrate antigen125 in the two groups were compared. Results： Before treatment,the high-sensitivity C-reactive protein levels in observation group was higher than the control group,with statistically significant difference（ t = 9. 8663,P〈0. 0001）; the carbohydrate antigen content in observation group was higher than the control group,with statistically significant difference（ t = 6. 9395,P〈0. 0001）; the positive rate of hypersensitive C-reactive protein in observation group and control group were 56. 00% and 0. 00% respectively,with statistically significant difference（ χ2=38. 8889,P〈0. 0001）; the positive rate of carbohydrate antigen 125 and high-sensitivity C-reactive protein in observation group were of no significant difference from that of the control group（ P〈0. 05）. After treatment,the percentage of high-sensitivity C-reactive protein,high-sensitivity C-reactive protein with carbohydrate antigen-positive 125 of observation group had no statistically significant difference compared with the control group（ P〉0. 05）. Conclusions： The high-sensitivity C-reactive protein and carbohydrate antigen 125 test has a high diagnostic value of endometrial cancer,acting a reference for the prognosis of patients.