孕晚期血清铁水平与子痫前期关系的Meta分析

Serum iron levels in preeclampsia in third trimester of pregnancy： A meta-analysis

目的 系统评价孕晚期血清铁水平与子痫前期发病的相关性. 方法 检索Pubmed、Web of science、中国期刊网全文数据库、万方数据库和维普数据库,收集2014年3月以前有关孕晚期铁水平和子痫前期的病例对照研究,筛选出符合入选标准的文献,进行Meta分析. 结果 共有21篇病例对照研究纳入分析,8篇文献将病例组分为子痫前期轻度和重度,轻度子痫前期（SMD=1.84,95％ CI为0.65～ 3.03）和重度子痫前期（SMD=2.82,95％ CI为1.52 ～4.13）孕晚期血清铁水平均高于对照组,差异有统计学意义.13篇文献以子痫前期为病例组,子痫前期血清铁水平高于对照组,但差异无统计学意义（SMD=0.39,95％CI为-0.34～ 1.12）. 结论 孕晚期血清铁水平与子痫前期发病关系密切.

Objective To investigate the association between serum iron concentrations in the third trimester of pregnancy and the occurrence of preeclampsia （PE） by a Meta-analysis. Methods Databases including PubMed, Web of Science, CNKI, WANFANG, and VIP were searched to identify case-control studies on iron levels in the third trimester of pregnancy and PE as of March 2014. Selected publications were included in the Meta-analysis. Results Twenty-one case-control studies were included. The results showed that serum iron level in preeclampsia was higher than that of control group, but without a difference being statistically significant [ SMD =0.39,95% CI： -0. 34-1.12, P =0.29]. Compared with control group, serum iron level in mild and severe PE were both higher, with both differences being significant [SMD=1.84,95% CI：O. 65-3. 03, P 〈0. 05; SMD =2. 82, 95% CI：I. 52-4. 13, P 〈0.0001, respectively]. Conclusion Serum iron levels in the third trimester of pregnancy were associated with occurrence of PE.