Vadimezan的简便合成

A Concise Synthesis of Vadimezan

2-氨基-3,4-二甲基苯甲酸经重氮化、溴代得到2-溴-3,4-二甲基苯甲酸,再与邻羟基苯乙酸醚化和在多聚磷酸中发生分子内傅-克酰化反应制得vadimezan,总收率为59%。

Vadimezan was synthesized from the diazotization and bromination of 2-amino-3,4-dimethylbenzoic acid, followed by etherification with 2-hydroxyphenylacetic acid, and intramolecular Friedel-Crafts acylation in polyphosphoric acid with a total yield of 59 %.