奥美拉唑治疗消化性溃疡的临床疗效观察

Efficacy and Safety of Omeprazole for Peptic Ulcer

目的:探讨奥美拉唑治疗消化性溃疡的效果及安全性。方法:选择122例消化性溃疡患者作为研究对象,采用随机数字表法将研究对象随机分为A组和B组。A组患者使用抗菌药物和胃黏膜保护剂进行治疗,B组患者在A组治疗的基础上同时接受奥美拉唑治疗。连续治疗4周后,比较两组患者的治疗效果和安全性。结果:B组总有效率明显高于A组,差异有统计学意义(P<0.05)。与A组相比,B组患者中位溃疡愈合时间较短,幽门螺杆菌根除率较高,平均抑酸持续时间较长,治疗费用较高,差异均有统计学意义(P<0.05);B组不良反应发生率明显高于A组,差异有统计学意义(P<0.05)。结论:奥美拉唑治疗消化性溃疡效果较好,但也会增加不良反应和治疗费用,在今后的临床工作中应予以重视。

OBJECTIVE：To investigate the efficacy and safety of omeprazole for treatment of peptic ulcer METHODS： 122 patients with peptic ulcer were randomly divided into group A and group B, with the group A receiving antimicrobial drugs plus gastric nmcosal protective agent alone, while group B receiving add-on omeprazole besides the therapy for group A. After four weeks of treatment, the two groups were compared with regard to the therapeutic efficacy and safety. RESULTS： The total effective rate was significantly higher in group B than in group A （P 〈 0.05）. In group B compared with group A, the median ulcer healing time was shorter, H. pylori eradication rate was higher, the mean duration of acid suppression was longer, and the cost of treatment was higher （P 〈 0.05） ; The incidence of adverse events was significantly higher in group B than in group A （ P 〈 0.05 ）. CONCLUSIONS ： Omeprazole is effective for peptic ulcer yet without adding side effect and added cost, which thus should be given great importance in future clinical practice.