191例慢性阻塞性肺疾病住院患者抗菌药物应用分析

Antibiotic Use in the Inpatients with Chronic Obstructive Lung Disease: Analysis of 191 Cases

目的:了解某院慢性阻塞性肺疾病(COPD)住院患者抗菌药物的使用情况。方法:组织临床药师对某院2011年度191例COPD住院患者抗菌药物使用情况、住院时间、病原学检查、治疗结果、血常规、肝肾功能检查次数、不良反应、不合理使用情况等进行统计分析。结果:某院COPD住院患者抗菌药物应用率为99.48%;应用频率排序前5位的药品分别为替卡西林-克拉维酸、头孢唑肟、哌拉西林-舒巴坦、左氧氟沙星、依替米星;二联用药占81.15%,三联及以上用药占9.95%。结论:某院COPD住院患者抗菌药物应用基本合理,但还需加强抗菌药物临床应用指征的严格把握,使COPD患者抗菌药物使用更加合理、规范。

OBJECTIVE：To investigate the antibiotic use in the inpatients with chronic obstructive puhnonary disease （COPD）. METHODS： Clinical pharmacists conducted a statistical analysis regarding the antibiotic use, length of hospital stay, etiology test, treatment outcome, frequency of the blood routine test and hepatorenal function tests, adverse drug reactions and analysis on irrational use of antibiotics etc in 191 COPD cases in 2001. RESULTS： The rate of antibiotic use was 99.48%. The top five antibiotic ranked by DDDs were Ticarcillin/Clavulanate Acid, Ceftizoxime, Piperacillin Sodimn/Subactam, Levofloxacin and Etimicin; the rate of two-drug combination accounted for 81.15% and the of the three-drug combination accounted for 12. 57%. CONCLUSIONS： The antibiotic use in the COPD inpatients in this hospital is rational on the whole; however, the indications for antibiotic use should be strictly followed in order to achieve more rational and standard use of antibiotics in patients with COPD.