紫杉醇治疗上皮性卵巢癌周疗与月疗的临床对比分析

Clinical Comparative Analysis Between Weekly and Monthly Paclitaxel Therapy for Treatment of Epithelial Ovarian Cancer

目的比较紫杉醇周疗和月疗两种给药方案治疗上皮性卵巢癌的临床效果。方法将近三年的30例上皮性卵巢癌患者分为dd-TC组(周疗)和c-TC组(月疗)各15例,两组均给予卡铂6mg/(m L·min)。c-TC组给予紫杉醇剂量为d1 3h内静脉输注180mg/m2,dd-TC组给予的紫杉醇剂量为d1、d8、d15 1h静脉输注80 mg/m2,每3周重复1次持续6个疗程,对于出现局部或全身反应的患者给予额外3个化疗疗程。结果 dd-TC组和c-TC组患者中位生存期存在统计学差异(P<0.01);卵巢癌治疗功能评价系统量表(FACT-O)的dd-TC组患者总评分与c-TC组患者存在明显差异(P<0.05),但在其中身体量表、社会量表、功能量表、心理量表和卵巢量表各项对比两组无明显差异(均P>0.05)。结论 dd-TC与c-TC相比可提高患者中位生存期,但在生活质量方面二者没有显著差异。

Objective To compare the clinical effect between weekly and monthly paclitaxel therapy for treatment of epithelial ovarian cancer. Methods 30 cases of epithelial ovarian cancer patients were divided into dd- TC group（weekly therapy） and c-TC group （month therapy） with 15 cases in each group. Both of the two groups were given carboplatin 6mg/（mL.min）.The c-TC group： paclitaxel was administered by intravenous infusion at a dose of 180mg/mz in 3 hours （day 1）;The dd-TC group： paclitaxel was administered by intravenous infusion at a dose of 80mg/m2 in 1 hours （days 1,8,15） every three week for 6 courses. Patients with local or systemic reactions were given three courses of chemotherapy treatment additionally. Results The median survival time of the two groups were statistically difference （P〈0.01）. FACT-O scale of the two groups were statistically difference （P〈0.05）. There were no differences in body scale, the social scale, function scale, psychological scale and ovarian scale between the two groups （P〉0.05）. Conclusion Compared with c-TC, dd-TC could improve the median survival time Of patients, but there were no differences in quality of life.＇