心肺复苏术后亚低温联合乌司他丁对脑保护的疗效观察

Clinical Efficacy of Mild Hypothermia Combined with Ulinastatin on Brain Protection After Successful Cardiopulmonary Resuscitation

目的探讨心肺复苏术后亚低温联合乌司他丁对脑保护的疗效。方法将心肺复苏(CPR)救治成功后昏迷患者88例分为对照组(28例)、亚低温组(30例)及亚低温联合乌司他丁组(30例)。对照组患者进行常规的对症支持治疗,亚低温组在常规治疗基础上采用亚低温治疗,联合组在常规治疗基础上采用亚低温联合乌司他丁治疗,观察三组患者的GCS、NFCS评分状况及通气时间、死亡率等。结果联合组7 d后的GCS评分显著高于对照组及亚低温组,P<0.05;联合组患者的GCS评分显著高于亚低温组及对照组,P<0.05,联合组的机械通气时间显著低于亚低温组及对照组,P<0.05。三组患者的死亡率比较无统计学差异。结论亚低温联合乌司他丁可更好保护脑部功能,加快脑部复苏,改善脑部神经功能,减少机械通气时间,值得应用。

Objective To explore the clinical efficacy of mild hypothermia combined with ulinastatin on brain protection after successful cardiopulmonary resuscitation. Methods 88 cases with coma after successful cardiopulmonary resuscitation（ crp） were divided into control group（ 28 cases）,mild hypothermia group（ 30 cases） and mild hypothermia ulinastatin group（ combination group = 30 cases）. Patients in the control group were treated with routine supportive treatment,the mild hypothermia group were treated with mild hypothermia therapy on the basis of conventional therapy,and the combined group were treated with mild hypothermia combined ulinastatin treatment on the basis of conventional therapy. The GCS,NFCS score condition and duration of mechanical ventilation,mortality,etc were compared among three groups. Results The GCS score after 7 days in the combination group was significantly higher than the hypothermia group and the control group,P 0. 05; the duration of mechanical ventilation of the combination group was significantly higher than the hypothermia group and the control group,P 0. 05. There was no significant difference in mortality among three groups. Conclusion Mild hypothermia Ulinastatin could better protect brain function,accelerate the recovery of the brain,improve brain nerve function,and reduce duration of mechanical ventilation,so it is worthy application.