摘要
目的:研究艾司西酞普兰对抑郁症的治疗效果和安全性。方法:收集本院于2013年1月-2014年4月接诊的80例抑郁症患者的临床病例资料,将所有接诊患者随机数字表分为观察组患者40例,采用艾司西酞普兰治疗,对照组40例,采用帕罗西汀治疗,比较两组患者的治疗效果。结果:治疗后2周、4周、6周,观察组较对照组患者的HAMD评分出现了明显改善,组间差异具有统计学意义(t=-2.968,-2.462,-1.991;P<0.05),观察组不良反应发生率均明显低于对照组患者,其中,出汗、口干、恶心呕吐、体重增加、视物模糊、头疼等不良反应的发生率组间具有统计学差异(χ2=4.114,5.591,4.013,5.165,5.165;P<0.05)。结论:采用艾司西酞普兰对抑郁症治疗的临床疗效发挥更快,可以更快地改善抑郁患者的临床症状,有利于提高抑郁患者的生活质量和改善患者的社会功能,其安全可靠,疗效确切,值得临床推广。
Objective:To study the efficacy and safety of escitalopram for the treatment of depression .Methods:A total of 80 patients with depression were divided into the observation group of 40 patients with escitalopram treat-ment and the control group of 40 patients with paroxetine treatment .The efficacy and safety for two groups were compared.Results:After two weeks,four weeks,six weeks,the observation group rather than in the control group of patients had a marked improvement in HAMD score , with statistically significant difference between groups ( P 〈0 .05 );Adverse reactions occurred in the observation group were significantly lower than those in the control group , including sweating,dry mouth,nausea,vomiting,weight gain,blurred vision,headaches,etc.(P〈0.05).Conclu-sion:Escitalopram for the treatment of depression can play earlier ,faster clinical improvement in patients with de-pression,which help to improve the quality of life of patients with depression and improve social function in pa -tients,and it is worthy of promotion .
出处
《中国健康心理学杂志》
2015年第2期164-166,共3页
China Journal of Health Psychology