艾司西酞普兰治疗抑郁症的有效性和安全性临床研究

Clinical Efficacy and Safety of Escitalopram for Treatment of Depression

目的:研究艾司西酞普兰对抑郁症的治疗效果和安全性。方法:收集本院于2013年1月-2014年4月接诊的80例抑郁症患者的临床病例资料,将所有接诊患者随机数字表分为观察组患者40例,采用艾司西酞普兰治疗,对照组40例,采用帕罗西汀治疗,比较两组患者的治疗效果。结果:治疗后2周、4周、6周,观察组较对照组患者的HAMD评分出现了明显改善,组间差异具有统计学意义(t=-2.968,-2.462,-1.991;P<0.05),观察组不良反应发生率均明显低于对照组患者,其中,出汗、口干、恶心呕吐、体重增加、视物模糊、头疼等不良反应的发生率组间具有统计学差异(χ2=4.114,5.591,4.013,5.165,5.165;P<0.05)。结论:采用艾司西酞普兰对抑郁症治疗的临床疗效发挥更快,可以更快地改善抑郁患者的临床症状,有利于提高抑郁患者的生活质量和改善患者的社会功能,其安全可靠,疗效确切,值得临床推广。

Objective：To study the efficacy and safety of escitalopram for the treatment of depression .Methods：A total of 80 patients with depression were divided into the observation group of 40 patients with escitalopram treat-ment and the control group of 40 patients with paroxetine treatment .The efficacy and safety for two groups were compared.Results：After two weeks,four weeks,six weeks,the observation group rather than in the control group of patients had a marked improvement in HAMD score , with statistically significant difference between groups （ P 〈0 .05 ）;Adverse reactions occurred in the observation group were significantly lower than those in the control group , including sweating,dry mouth,nausea,vomiting,weight gain,blurred vision,headaches,etc.（P〈0.05）.Conclu-sion：Escitalopram for the treatment of depression can play earlier ,faster clinical improvement in patients with de-pression,which help to improve the quality of life of patients with depression and improve social function in pa -tients,and it is worthy of promotion .