干细胞移植治疗脓毒症的研究进展

Research progress on the mesenchymal stem cells to treat sepsis

脓毒症是以全身炎症反应综合征为表现的一组临床综合征，现有的治疗方法不能取得满意的疗效，死亡率仍然居高不下。研究证实，骨髓间充质干细胞（MSCs）具有再生修复功能和强大的免疫调节以及抗炎功能。借此干细胞移植能从整体上调节宿主免疫和炎症反应，同时还能修复受损的组织和器官，有望成为脓毒症救治的新希望。

Sepsis is a syndrome with clinical manifestation of SIRS. It remains a high mortality even under proper critical care and available treatment. The recent studies confirmed that mesenchymal stem cells （MSCs） have regeneration-dependent tissue repair function, anti-inflammation ability and immunomodulation property. Therefore, the MSCs transplant may be a new promising strategy to treat sepsis, which through regulate immunoreaction, recover the inflammation balance and repair the impaired organs.