白细胞介素-27的生物学功能及其抗病毒作用的研究进展

Progress in the research on biological functions of interleukin-27 and it＇ s antiviral effect

白细胞介素．27（IL-27）是IL-6／IL-12细胞因子家族成员之g ，由EB13和p28两个亚基构成异源二聚体，主要来源于树突状细胞（DCs）的分泌。IL-27受体（IL-27R）由WSX-1与gp130共同组成，多种细胞中均有IL-27R的表达。IL-27对免疫细胞尤其Thl细胞、Th2细胞、Th17细胞、调节性T细胞（Treg）的发育、分化和功能都发挥着不可或缺的作用，它具有免疫促进和免疫抑制双重特点。IL-27的抗病毒作用-直是近年研究的热点，它在抗HIV的研究中较多，对HBV的抗病毒作用也得到了证实。因而IL-27在抗病毒复制中发挥重要作用。

Interleukin-27 （IL-27） is a member of the IL-6/IL-12 cytokine family that consists of Ep- stein-Barr virus induced gene 3 （EBI3） subunit and p28 subunit. It is mainly secreted by dendritic cells （DCs）. IL-27 receptor,which is composed by WSX-1 and gpl30, is expressed by a variety of cells. IL-27 plays an important role on the development, differentiation and function of immunoeells, especially Thl cells, Th2 ceils, Thl7 cells and Treg ceils. IL-27 has both promoting and inhibitory effect on the immune response. The antiviral effect of IL-27 has been a research hotspot in recent years. The anti HIV-1 and antiviral HBV effect of IL-27 has also been demonstrated. In short, IL-27 plays an important role in the antiviral responses.