顶空气相色谱检测甘草苷中大孔吸附树脂残留物

Gas Chromatography Detection of Organic Residues of Macroreticular Resin in Liquiritin

目的：建立顶空气相色谱测定甘草苷中大孔吸附树脂有机残留物的含量。方法：采用HP-INNOWAX石英毛细管柱（0.32 mm×30 m,0.25μm）;以N,N-二甲基甲酰胺为溶剂,对正己烷、丙酮、苯、甲苯、二甲苯、苯乙烯等残留物进行检测。结果：被测物质均能得到很好的分离,RSD均〈3.0%,峰面积与浓度线性关系良好,回收率为93.2%-100.7%。结论：该方法稳定、准确,适用于应用D-101型大孔吸附树脂纯化后原料药中有机溶剂残留物的检测。

Objective： To build up a headspacemethod for detecting organic residues of D-101 macroreticular resin in liquiritin.Method： Using HP-INNOWAX capillary column（0.32mm × 30m,0.25μm）.The purpose was to detect hexane,acetone,benzene,toluene,xylene,styrene and other residues,using N,Ndimethyl formamide as solvent.Result： Analytes can be well separated,the RSD were less than 3.0%,peak area and concentration had a good linear relationship,the recoverywas 93.2%-100.7%.Conclusion： This method is stable,accurate and suitable for use D-101 macroporous resin after the detection of residues of organic solvents.