绿原酸的肠道菌群代谢研究进展

Advances in study on gut flora metabolism of chlorogenic acid

中药多数是以口服的形式进入消化道,而肠道难以吸收、在肠道内滞留时间较长的中药化学成分则更易受到肠道菌群的作用。肠道内微生物对中药的代谢发挥着重要作用。绿原酸作为许多中药的主要活性成分,应用日趋广泛,其体内代谢的研究也备受关注。在胃和小肠中,仅约1/3的绿原酸被吸收,大肠尤其富含菌群的结肠是绿原酸的主要代谢吸收场所。针对绿原酸的体内外肠道菌群代谢研究进行了综述,总结相关代谢产物,为进一步研究绿原酸在体内的作用机制提供参考。

Most of the Chinese materia medica（CMM） come into the digestive tract in the form of oral administration. Chemical constituents of being difficult in intestinal absorption or having long retention time in the gastrointestinal tract are more easier to be affected by gut flora. Many microbes in the intestinal tract play an important role in the metabolism of CMM. As one of the main active ingredients in many CMM, chlorogenic acid is getting a growing attention, especially its metabolism. In the stomach and small intestine, only about a third of chlorogenic acid is absorbed; Large intestine, especially colon with rich flora is the main metabolic absorption site of chlorogenic acid. This article mainly reviews in vivo and in vitro studies on the gut flora metabolism of chlorogenic acid and summarizes corresponding metabolic products, in order to provide the reference for further study of in vivo activities of chlorogenic acid.