医用金属材料离子释放机制、致病机理及防护

Metal Ions Release Mechanism from Metallic Biomaterials and Their Pathogenic Mechanism and Protection

结合近年来国内外医用钛合金等金属材料在生物体和人体临床应用研究成果,研究了人体植入物等医用金属材料中Ni、Al、V等有害离子的释放机制、致病机理及防护(涂层)方法。系统分析了常用医用金属材料Ti6Al4V和Ti Ni形状记忆合金等钛合金在腐蚀等作用下有害离子的释放机制,有害离子及其形成化合物对人体的毒性作用,和常用表面改性技术制备涂层对于有害离子的抑制和防护作用。研究结果表明,近年来发展起来的表面改性技术显著提高钛合金耐蚀性,可以有效抑制有害离子的释放,提高钛合金的生物相容性。

Based on the research and development of titanium alloys for biomedical applications in China and abroad during the past few years, the metal ions release mechanism from titanium-based alloys, and their pathogenic mechanism and protective coatings and measurements were investigated. A systematic analysis is made of the effect of the corrosion on the metal ions release mechanism from the Ti6Al4 V alloy and Ti Ni shape memory alloy, of the relationship of metal ions with pathogenic mechanism of some diseases, and of the protective coatings and surface modification techniques inhibiting the release of the metal ions. It shows that a large number of surface modification techniques were developed in recent years to improve the biocompatibility and corrosion resistance of titanium alloys and the release of metal ions were inhibited.