达比加群酯在小面积肺栓塞中的疗效观察

Observation on Effect of Dabigatran on Small Area of Pulmonary Embolism

目的:观察达比加群酯(dabigatran)在治疗小面积肺栓塞(单个肺叶阻塞)中的疗效并讨论其安全性。方法:108例符合小面积肺栓塞诊断标准的患者,随机分为治疗组(56例)和对照组(52例)。治疗组患者口服达比加群酯110mg,2次/日,服用3个月;对照组患者口服华法令5mg,服用3个月。通过回访、复查,对两组在症状控制、主要终点事件及不良反应发生的情况等方面做出评价疗效。结果:达比加群酯抗凝有效(P<0.05),出血并发症与华法令比较差异无显著性(P>0.05)。结论:达比加群酯在治疗小面积肺栓塞中的抗凝效果明显有效。

Objective：To investigate the effect of dabigatran on small area of PE（with single lobe obstruc-ted）and its safety.Methods：Select 108 cases who are up to the diagnisis criteria of small area PE and ran-domly divide them into the treatment group （56 cases）and control group（52 cases）.in the treatment group, the patients orally took 110 mg of dabigatran twice a day for three monthes while in the control group,the patients orally took 110mg of warfarin for 3 monthes .Pay a return visit to them and review the condition ,e-valuate the effect according to the control of symptoms ,the occurrence of main outcome events and adverse reaction and other aspects.Results：It was effective to anticoagulate with dabigatran （P＆lt;0.05）,compared with warfarin,there was no obvious difference on bleeding symptoms.Conclusion：Dabigatran is effective to treat small area PE,and its anticoagulatnt effect is obvious.