人诱导多能干细胞体外诱导产生红细胞的研究进展

The research advances on human induced pluripotent stem cells in vitro to produce red blood cells

诱导多能干细胞(iPSCs)不仅具有无限增殖的能力,还可以根据不同的需要筛选出特定的表型,iPSCs可定向诱导生成RBC,作为RBC输血的一个新来源。要将此技术应用到临床输血上,还需对一些关键程序进行优化,如用于生成iPSCs的细胞类型的选择、改进用于保障临床应用安全的重编程方法、红细胞分化过程的优化等。

Induced pluripotent stem cells（iPSCs） not only have the ability to proliferate indefinitely,but can filter according to different needs of particular phenotypes.Furthermore,i PSCs could be directionally induced to produce red blood cells（RBC） and provide a new source for RBC transfusion.However,the application of this technology to the clinical transfusion still needs optimizations on several key steps,such as the selection of types of cells which produce i PSCs,the improvement on reprogramming methods that could be applied to guarantee the safety of clinical applications,and the optimization of erythrocyte differentiation process.