我院110例高血脂患者他汀类药物使用调查与分析

Investigation and Analysis of Clinical Application of Statin Drugs in 110 Patients with High Cholesterol in Our Hospital

目的:为高血脂患者合理使用他汀类药物提供参考。方法:随机抽取2012-2013年我院血脂检查异常并符合他汀类药物用药条件的患者110例,调查其对他汀类药物的使用情况或未使用该类药物的原因。6个月后统计患者的血脂达标情况。结果:110例患者中,按照医嘱服用他汀类药物患者46例(41.82%)在体检中30例(65.22%)达标;服用他汀类药物的剂量不足23例(20.91%),在体检中8例(34.78%)达标;使用其他调脂药24例(21.82%),在体检中8例(33.33%)达标;17例(15.45%)患者未使用调脂药,在体检中1例(5.88%)达标。共有64例患者未按照医嘱服用他汀类药物,主要原因包括患者因自身知识缺乏而担心药品不良反应、经济负担重和医师处方原因(处方中他汀类药物与其他药物有相互代谢作用)。结论:他汀类药物能明显改善血脂异常患者的血脂水平,医务人员应加强对患者的用药教育,以提高高血脂患者服用他汀类药物的依从性。

OBJECTIVE：To provide reference for rational use of statin drugs in patients with high cholesterol. METHODS：In total of 110 patients with dyslipidemia were randomly selected who complied with the condition of statin medication in our hospital from 2012 to 2013. The patients’ use of statin drug or the reasons why the patients did not use statin drug were investigated. The cholesterol levels of the patients were examined after 6 months. RESULTS：Among the 110 patients,46 cases（41.82%）were using statin drugs as prescribed with 30 cases standard（65.22%）,23 cases（20.91%）taking inadequate doses of statins with 8 case standard（34.78%）,24 cases（21.82%）with other lipid-lowering agents with 8 cases standard（33.33%）and 17 cases（15.45%）without any lipid-lowering drugs with 1 case standard（5.88%）. There were totally 64 cases were not using statin drugs as prescribed,the reasons were fearing of drug adverse reactions due to the lack of knowledge,the economic burden and doctor’s prescription（Statins had mutually metabolism with other drugs）. CONCLUSIONS：Statins can significantly improve lipid levels in patients with dyslipidemia. The medical staff should strengthen patient medication to improve the medication compliance of the patients with high cholesterol.