瑞舒伐他汀钙对老年缺血性脑卒中患者S100A8、S100A9、Hcy和NPY水平的影响

Effect of Rosuvastatin on S100A8,S100A9,Hcy and NPY Levels in Aged Patients with Ischemic Stroke

目的:研究瑞舒伐他汀钙强化调脂对老年缺血性脑卒中(IS)患者血清S100钙结合蛋白A8(S100A8)、S100钙结合蛋白A9(S100A9)、同型半胱氨酸(Hcy)和神经肽Y(NPY)水平的影响。方法:选取2008年2月-2012年12月于我院神经内科住院的82例老年IS患者为研究对象,按照随机数字表法分为观察组与对照组,各41例。对照组仅给予常规IS对症支持治疗,而观察组则在此基础之上加用瑞舒伐他汀钙(20 mg,qd,疗程6个月)。比较两组患者血脂、颈动脉超声检测参数、脑卒中量表评分、Barthel指数和血清S100A8、S100A9、Hcy和NPY的变化水平。结果:治疗前两组患者的血脂指标甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),颈动脉超声参数内膜中层厚度(IMT)、扩张性、僵硬度、斑块指数,美国国立卫生研究院脑卒中量表(NIHSS)评分、Barthel指数及Hcy、S100A8、S100A9和NPY的水平比较差异无统计学意义(P>0.05);但治疗结束后,两组患者的IMT、僵硬度、斑块指数、NIHSS评分及Hcy、S100A8、S100A9和NPY的水平均明显低于治疗前,且Barthel指数显著增加(P<0.05);而对照组患者仅TC低于治疗前(P<0.05),TG、LDL-C、HDL-C则无显著改变(P>0.05),且扩张性也仅观察组患者出现明显增加(P<0.05),对照组患者亦无明显变化(P>0.05)。此外,观察组患者的上述指标的变化程度均明显优于对照组,差异有统计学意义(P<0.05)。结论:瑞舒伐他汀钙强化调脂可改善老年IS临床症状,促进颈动脉血流的循环,降低S100A8、S100A9、Hcy和NPY的含量水平。

OBJECTIVE：To investigate the effect of rosuvastatin intensive lipid-lowering therapy on the serum S100 calcium binding protein A8（S100A8）,serum S100 calcium binding protein A9（S100A9）,homocysteine（Hcy） and neuropeptide Y（NPY）levels in aged patients with ischemic stroke（IS）. METHODS：82 IS aged patients in our hospital during Feb. 2008 to Dec.2012 were selected as research objective and randomly divided into observation group and control group with 41 cases in each group. Control group only received routine IS treatment,and observation group was additionally given rosuvastatin（20 mg,qd,for 6 months） on the basis of control group. Blood lipid,carotid artery ultrasound parameters,stroke scale score,Barthel index and serum S100A8,S100A9,Hcy and NPY were compared between 2 groups. RESULTS：Before treatment,there were no significant difference between 2 groups in TG,TC,LDL-C,HDL-C,carotid artery ultrasound parameters IMT,expansion,stiffness,plaque index,NIHSS score,Barthel index,Hcy,S100A8,S100A9 and NPY levels（P〉0.05）. After treatment,IMT,stiffness,plaque index,NIHSS score,Barthel index and Hcy,S100A8,S100A9 and NPY levels of 2 groups were significantly lower than before,and Barthel index was significantly increased（P〈0.05）;in control group,only TC was lower than before（P〈0.05）;TG,LDL-C and HDL-C showed no significant change（P〉0.05）;the expansion was also increased significantly only in observation group（P〈0.05）,while there was no significant change in control group（P〉0.05）. In addition,the change degree of indexes mentioned above in observation group were significantly better than in control group;there was statistical significance（P〈0.05）.CONCLUSIONS：Rosuvastatin intensive lipid-lowering therapy can improve the clinical symptoms of IS,promote the carotid artery blood circulation and reduce the levels of S100A8,S100A9,Hcy and NPY.