对质子泵抑制剂预防抗栓药消化道损伤的药学干预

Pharmacy Intervention of Proton Pump Inhibitors on Preventing the Risk of Digestive Tract Lesion Caused by Antithrombotic Drugs

目的:为促进质子泵抑制剂(PPIs)的合理应用提供参考。方法:收集临床药师干预前(2013年4-7月)使用抗栓药住院病历202份,临床药师干预后(2014年4-7月)使用抗栓药住院病历227份,比较两组患者临床资料及预防性使用PPIs不合理情况。结果:PPIs预防性应用率干预前为88.6%(179/202),干预后下降至50.7%(115/227)(P<0.05);PPIs药品费用干预前为(601.94±145.34)元,干预后下降至(144.91±43.65)元(P<0.01);与干预前比较,干预后PPIs的各项不合理用药均显著降低(P<0.01);干预前后抗栓药引起消化道损伤症状发生率差异无统计学意义(P>0.05)。结论:临床药师对PPIs预防抗栓药消化道损伤的药学干预可行、有效,促进了PPIs的合理使用。

OBJECTIVE：To provide reference for the improvement of rational application of proton pump inhibitors（PPIs）.METHODS：In total of 202 medical records of patients with antithrombotic drugs before intervention from Apr. to Jul. 2013 and 227 medical records of patients with antithrombotic drugs after intervention from Apr. to Jul. 2014 were collected. Clinical data and irrational use of PPIs were compared between the two groups. RESULTS：Preventive use rate of PPIs was decreased from 88.6%（179/202）to 50.7%（115/227）（P〈0.05） before and after treatment. Costs of PPIs drugs were decreased from（601.94 ± 145.34） yuan to（144.91±43.65）yuan,respectively（P〈0.01）,Compared with before treatment,irrational use of PPIs was significantly decreased after intervention（P〈0.05）. There was no significant difference in the occurrence rate of digestive tract lesion caused by antithrombotic drugs’ before and after intervention（P〉0.05）. CONCLUSIONS：Clinical pharmacists’ intervention of proton pump inhibitors on preventing the risk of digestive tract lesion caused by antithrombotic drugs is feasible and effective and promote its rational clinical use.