MMP-2及TIMP-2在正常足月妊娠与妊娠期高血压疾病胎盘组织中的表达

Expression of MMP-2 and TIMP-2 in placenta organization of normal full- term pregnancy and hypertensive disorder complicating pregnancy

目的探究基质金属蛋白酶-2（matrix metallopreteinases-2,MMP-2）与基质蛋白酶组织抑制因子-2（tissue inhibitor of metallopreteinases-2,TIMP-2）在正常足月妊娠与妊娠期高血压疾病胎盘组织中的表达。方法选择2012~2014年陕西中医学院第二附属医院妇产科收治的住院期间诊断有妊娠期高血压疾病的产妇60例作为观察组,健康正常足月妊娠的产妇60例作为对照组。检测分析两组产妇胎盘MMP-2与TIMP-2的表达情况。结果两组产妇TIMP-2水平比较差异无统计学意义（P〉0.05）;观察组MMP-2水平与免疫组化积分均显著低于对照组（P〈0.05）。结论 MMP-2在妊娠期高血压疾病产妇的胎盘组织内呈低表达,导致胎盘组织内滋养细胞的浸润能力明显下降,与产妇妊娠期高血压疾病的发病密切相关,是胎盘发生病理改变的基础。

Objective To explore the expression of matrix metallopreteinases- 2（ MMP- 2） and tissue inhibitor of metallopreteinases- 2（ TIMP- 2） in placenta organization of normal full- term pregnancy and hypertensive disorder complicating pregnancy. Methods 60 cases with hypertensive disorder complicating pregnancy in the The Second Affiliated Hospital of Shanxi College of Traditional Chinese Medicine from 2012 to 2014 were selected as observation group. 60 cases of normal full- term pregnancy were selected as control group,The expression of MMP- 2 and TIMP- 2 of two groups were measured. Results TIMP- 2 level between two groups had no statistically significant difference（ P〉0. 05）. MMP- 2 level and immunohistochemical integral in observation group were significantly lower than the control group（ P〈0. 05）. Conclusion The MMP- 2 has a low expression in placenta organization of hypertensive disorder complicating pregnancy leading to the invasion ability of trophoblast cells in placenta tissues decreased significantly,which is closely related to hypertensive disorder complicating pregnancy and the basis of placenta pathological change.