地特胰岛素联合米格列醇治疗磺脲类继发失效2型糖尿病疗效观察

Clinical Observation of Insulin Determir Combined with Miglitol in Type 2 Diabetes Mellitus with Secondary Failure of Sulphonylureas

目的:探讨地特胰岛素联合米格列醇治疗磺脲类继发性失效2型糖尿病的疗效。方法:72例患者按随机数字表法分为治疗组(A组)和对照组(B组)各36例;A组给予地特胰岛素联合米格列醇治疗,B组给予皮下注射门冬胰岛素30R,治疗12周。比较治疗前后两组空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb Alc)、血糖达标率及低血糖率。结果:两组治疗前后FBG、2 h PG和Hb Alc均明显下降(P<0.05),但两组治疗后比较差异无统计学意义(P>0.05)。A组低血糖率低于B组(P<0.05)。结论:地特胰岛素联合米格列醇治疗磺脲类继发性失效2型糖尿病方便、安全、有效。

Objective： To observe the effect of insulin Determir combined with miglitol in treatment of secondary failure-to sulfonylureas in type 2 diabetes mellitus.Method： 72 cases were randomly divided into group A and group B, 36 eases of each group.The group A was treated with insulin Determir combined with Miglitol, while group B was given subcutaneous injection of insulin Aspart 3OR.Both groups were treated for 12 weeks. The fasting plasma glucose （ FBG ）, 2-hour postprandial plasma glucose （ 2 h PG ）, glycosylated hemoglobin （ HbAlc ）, the control rate and incidence of low blood glucose before and after treatment of the two groups were compared.Result： After treatment, the FBG, 2 h PG and HbAlc of two groups were remarkably decreased, and the differences were statistically significant （ P〈0.05 ） . But there were no statistical significance between two groups after treatment （ P〉0.05 ） .And in the A group , the rate of hypoglycemia was lower than in B group （ P〈0.05 ） .Conclusion： Insulin Determir combined with Miglitol is convenient, safe and effective with secondary failure of Sulphonylureas in type 2 diabetes mellitus.