丹参多酚酸盐对急诊PCI患者术后MDA、NADPH氧化酶p22phox活性的影响

Effects of Salvianolate on MDA, NADPH Oxidase P22phox in Patients with Primary Percutaneous Coronary Intervebtion

目的:研究丹参多酚酸盐对急性ST段抬高型心肌梗死急诊PCI患者术后MDA、NADPH氧化酶p22phox活性的影响,从而探讨其在氧化应激方面的作用。方法:选择83例急性ST段抬高型心肌梗死行急诊PCI治疗的患者,随机数字表法分为对照组37例和治疗组46例,对照组包括双抗血小板、抗凝、调脂等治疗,治疗组在对照组治疗的基础上+丹参多酚酸盐注射液200 mg/d静滴。分别测定入院即刻及治疗后2周的血清MDA(丙二醛)浓度水平、外周血吞噬细胞NADPH氧化酶(细胞还原型辅酶Ⅲ氧化酶)p22phox活性水平,分别比较两组患者入院时及治疗后2周以上各指标的变化,以及两组间治疗后的变化情况,同时观察药物不良反应。结果:(1)治疗组治疗后2周MDA水平、NADPH氧化酶p22phox活性水平较入院时均明显降低,比较差异均有统计学意义(P<0.05)。(2)对照组治疗后2周MDA、NADPH氧化酶p22phox活性水平较入院时均有降低趋势,但比较差异无统计学意义。(3)治疗组治疗后2周MDA水平、NADPH氧化酶p22phox活性较对照组明显降低,比较差异均有统计学意义(P<0.05)。结论:丹参多酚酸盐可明显降低血清MDA水平及外周血吞噬细胞NADPH氧化酶p22phox活性活性,其机制可能与抑制氧化应激有关。

[ Abstract ] Objective： To study the effects of salvianolate on MDA, NADPH oxidase p22phox in patients with Primary Percutaneous Coronary Intervebtion, explore the role of salvianolate in retarding oxidative stress.Method： 83 patients with Primary Percutaneous Coronary Intervebtion were divided randomly into therapy group （ 46 eases ） and control group （ 37 cases ） .Therapy group was treated with salvianolate （ 200 mg/d ） and antiplatelet, anticoagulation, blood fat adjustment.And control group was treated with simple ntiplatelet, anticoagulation and blood fat adjustment.MDA, NADPH oxidase p22phox and adverse effect of salvianolate were observed on admission and 2 weeks after treatment. Result： （ 1 ） Expression of phagocytic NADPH oxidase p22phox and MDA in therapy group was both lower significantly after treatment （ P〈0.05 ） . （ 2 ） Expression of phagocytic NADPH oxidase p22phox and MDA of control group was lower after treatment, but the difference was not significant. （ 3 ） Expression of phagocytic NADPH oxidase p22phox and MDA of therapy group after treatment was lower significantly than that of control group （ P〈0.05 ） .Conclusion： Salvianolate could depress MDA and phagocytic NADPH oxidase p22phox, and its mechanism may be by retarding oxidative stress.