替米沙坦和氯沙坦对肾性高血压合并高尿酸血症的影响

The influence of telmisartan and losartan on renal hypertension compli-cated with hyperuricemia

目的探讨替米沙坦和氯沙坦对肾性高血压合并高尿酸血症的影响。方法选取2012年3月~2013年3月本院收治的32例肾性高血压合并高尿酸血症患者,将其随机分为A、B组,每组各16例。A组给予替米沙坦80 mg/d,B组给予氯沙坦50 mg/d,比较两组治疗前、治疗6周后的平均动脉压（MAP）、血尿酸（SUA）、Ccr、24 h尿尿酸（24 h UUA）等指标。结果治疗6周后,两组的MAP均较治疗前显著下降（P〈0.05）,两组治疗后的MAP差异无统计学意义（P〉0.05）;B组的24 h UUA较治疗前显著上升（P〈0.01）,SUA较治疗前显著下降（P〈0.01）。结论替米沙坦和氯沙坦的降压疗效相似,氯沙坦除有降压作用外,还可降低SUA水平,对肾性高血压伴高尿酸血症患者,应首选氯沙坦作为降压药。

Objective To investigate the influence of telmisartan and losartan on renal hypertension complicated with hyperuricemia. Methods 32 patients with renal hypertension complicated with hyperuricemia treated in our hospital from March 2012 to March 2013 were randomly selected and they were divided into the group A（n=16） and group B（n=16）.The group A was given telmisartan for 80 mg every day,while the group B was given losartan for 50 mg every day,the mean arterial pressure（MAP）,serum uric acid（SUA）,Ccr,24 hours uric uric acid（24 h UUA） and other indicator before treatment and after 6 weeks treatment in the two groups were compared. Results After 6 weeks treatment,MAP was obviously reduced respectively in the two groups compared with before treatment（P〈0.05）,and there was no statistical difference of MAP after treatment between the two groups（P〈0.05）;24 h UUA of of the group B was obviously increased compared with before treatment（P〈0.01）,SUA of the group B was obviously reduced compared with before treatment（P〈0.01）. Conclusion Antihypertensive effect of telmisartan and losartan is similar,losartan can reduce the SUA level except for antihypertensive effect,and losartan should be preferred to be as the antihypertensive drug.