神经肽降钙素基因相关肽、血管活性肠肽神经肽、Y检测在重型肝炎诊断中的意义

Application of neuropeptide CGRP,VIP,NPY detection in the diagnosis of severe hepatitis

目的:探讨神经肽CGRP(降钙素基因相关肽)、VIP(血管活性肠肽)、NPY(神经肽Y)检测在重型肝炎诊断中的意义。方法:选取近两年收治的66例重型肝炎患者为观察组,同时纳入66例正常人为对照组。检测并记录两组人员血清中神经肽CGRP、VIP、NPY水平及血浆内毒素水平。结果:对照组患者血清神经肽CGRP、VIP、NPY水平均低于观察组,组间比较差异有统计学意义(P<0.05);对照组患者血浆内毒素水平明显低于观察组(P<0.05),观察组患者水平逐渐升高,且随着病情的加剧而增加。结论:重型肝炎患者血清神经肽水平明显高于正常人,且其水平高低与病情轻重相关。

Objective： To investigate the effect of neuropeptide CGRP,VIP,NPY detection in the diagnosis of severe hepatitis. Sixtysix cases of severe hepatitis patients with methods in our hospital in the recent 2 years as the research object,were classifed into the observation group,while 66 normal persons were classified into control group. the neuropeptide CGRP,VIP,NPY levels and endotoxin levels were measured and recorded in the serum of patients with two groups,CGRP,VIP,NPY. Results： The serum neuropeptide levels were lower than the control patients in the observation group,the comparison between the two groups had obvious difference（ P 0. 05）; the serum levels of endotoxin group was significantly lower than the patients in the observation group,and increased with the intensification of the disease,the comparison between the two groups had statistical significance（ P 0. 05）. Conclusion： Serum neuropeptide levels in severe hepatitis is higher than that in normal controls,and its level of severity and prevalence is proportional to the disease condition.