多巴胺联合酚妥拉明对小儿肺炎合并心力衰竭的疗效及心肌酶的影响

Effects of Dopamine Plus Phentolamine on Infantile Pneumonia Complicated with Heart Failure and Myocardial Enzyme

目的探讨多巴胺联合酚妥拉明对小儿肺炎合并心力衰竭的疗效及心肌酶的影响。方法将114例小儿肺炎合并心力衰竭患儿根据随机数字表法将其分为对照组（ n＝57）和观察组（ n ＝57）；对照组采用酚妥拉明治疗，观察组在对照组基础上加用多巴胺。两组患儿均以7d为1疗程。结果观察组治疗后总有效率（92．89％）显著高于对照组治疗后总有效率（77．19％），且差异有显著性意义（ P ＜0．05）；观察组治疗后血清乳酸脱氢酶和血清肌酸激酶同工酶均显著低于其治疗前及对照组治疗后，且差异有显著性意义（P ＜0．05）；观察组治疗后呼吸困难、紫绀、啰音消失、心力衰竭控制时间及住院时间均明显短于对照组，且差异有显著性意义（ P ＜0．05）；两组患儿均未发生明显不良反应。结论多巴胺联合酚妥拉明对小儿肺炎合并心力衰竭的疗效显著，且可改善患儿心肌酶，值得临床进一步推广应用。

[Objective]To explore the effects of dopamine plus phentolamine on infantile pneumonia com‐plicated with heart failure and myocardial enzyme so as to provide rationales clinical diagnosis and treatment .[Methods]A total of 114 children with pneumonia complicated with heart failure were randomly divided into two groups of control （A ,n =57） and observation （B ,n =57） .The control group received phentolamine a‐lone for 7 days while the observation group had both phentolamine and dopamine for 7 days .[Results]The o‐verall treatment efficiency was significantly higher in group B than that in group A （92 .89% vs 77 .19% ） and the difference had statistical significance （ P〈0 .05）;In observation group after treatment ,the serum levels of lactate dehydrogenase and creatine kinase were significantly lower than those before treatment and control group after treatment .And the difference had statistical significance （ P 〈0 .05） .In observation group after treatment ,dyspnea ,cyanosis and rales disappeared .And failure to control time and hospital stay were signifi‐cantly shorter than those in control group .And the difference had significant statistical significance （ P〈0 .05） .Neither group had an onset of marked adverse reactions .[Conclusion]The efficacy of dopamine plus phentolamine is definite for pneumonia in children with heart failure .And it improves patient enzymes and is worthy of wider applications .