不同组合治疗方案对90例溃疡性结肠炎的疗效观察

The Efficacy of Treatment Options for Different Combination Therapy Programs in Treatment of 90 Ulcerative Colitis Patients

目的:通过对溃疡性结肠炎不同方案治疗观察,评价其疗效差异。方法:选择2011年6月-2013年6月本院消化科住院治疗的90例溃疡性结肠炎住院患者作为研究对象,随机数字表法分为三组:A组:口服美沙拉嗪肠溶片治疗;B组:中药灌肠治疗;C组:口服中药联合中药灌肠治疗,每组各30例,比较三组治疗前后白细胞数计数、C反应蛋白水平、血红蛋白浓度以及治疗有效率。结果:(1)三组治疗前白细胞数计数、C反应蛋白水平、血红蛋白浓度比较,差异无统计学意义;三组治疗后白细胞数计数、C反应蛋白水平、血红蛋白浓度比较,差异有统计学意义(P<0.05),且C组明显优于A组、B组;(2)A组总有效率为63.3%,B组总有效率为80.0%,C组总有效率为93.3%,A、B组比较差异有统计学意义(P<0.05),且C组疗效显著优于B组(P<0.05)。结论:中医在溃疡性结肠炎的临床治疗中具有明显优势,而口服中药联合灌肠治疗对于溃疡性结肠炎的疗效优于单独中药灌肠治疗,可以更有效改善症状,促进肠道黏膜修复。

Objective： To evaluate the efficacy difference of different combination treatment programs in treatment of ulcerative colitis patients.Method： 90 ulcerative colitis patients were selected from our hospital gastroenterology during June 2011 and June 2013, they were divided into three groups. Group A： mesalamine enteric tablets treatment; Group B： enema treatment; Group C： oral medicine combined with enema therapy, each group contained 30 patients, WBC counts, C-reactive protein levels, hemoglobin concentration before and after treatment, and treatment efficiency was analyzed and compared.Result： （1） Before treatment, in WBC count, C-reactive protein level, hemoglobin concentration, the three groups had no significant difference （P〉0.05）. After treatment, in WBC count, C-reactive protein level, hemoglobin concentration, the difference between the three groups was statically significant （P〈0.05）, and Group C was better than Group A and Group B. （2） The total effective rate of the Group A was 63.3%, Group B was 80.0%, Group C was 93.3%, there were significant differences （P〈0.05）. Between the Group A and the Group B in total effective rate, and Group C was significantly better than Group B （P〈0.05）.Conclusion： TCM has obvious advantages in the clinical treatment of ulcerative colitis, oral medicine combined with enema therapy is better than along enema therapy, and it can be more effective in improving symptoms and promote intestinal mucosal repair.