健胃愈疡片修复内镜治疗术后“医源性溃疡”

Jianweiyuyang Pills Repair the Iatrogenic Ulcer after“ the Endoscopic Therapy”

目的:比较健胃愈疡片和雷贝拉唑胶囊修复内镜治疗术后"医源性溃疡"的临床价值。方法:对内镜下应用氩等离子凝固疗法(APC)、内镜黏膜切除术(EMR)、内镜黏膜下剥离术(ESD)治疗术后"医源性溃疡"的患者,口服健胃愈疡片(n=53)、雷贝拉唑胶囊(n=50)进行临床对照治疗,观察两组药物对"医源性溃疡"修复情况。结果:两组治疗期间未见胃窦黏膜出血、穿孔等并发症。健胃愈疡片组末次治疗术后1个月复查"医源性溃疡"呈红色溃疡瘢痕(S1期)48例(90.6%),术后3个月呈白色溃疡瘢痕(S2期)52例(98.1%),术后6个月超声内镜(EUS)显示为Sc期50例(94.3%)。雷贝拉唑组末次治疗术后1个月复查"医源性溃疡"呈红色溃疡瘢痕(S1期)47例(94.0%),术后3个月呈白色溃疡瘢痕(S2期)45例(90.0%),术后6个月EUS显示表现为Sc期40例(80.0%)。健胃愈疡片组溃疡愈合质量达Sc期患者优于雷贝拉唑胶囊组,两组比较差异有统计学意义(P<0.05)。结论:健胃愈疡片、雷贝拉唑胶囊治疗"医源性溃疡"短期效果相当,远期效果(溃疡愈合质量达Sc期)健胃愈疡片组优于雷贝拉唑胶囊组,笔者认为健胃愈疡片是一种治疗"医源性溃疡"较为理想的药物,可供临床选择应用。

Objective：To compare the clinical value of taking Jianweiyuyang pills and Rabeprazole capsules to repaire the iatrogenic ulcer after the Endoscopic therapy.Method：The patients who used the iatrogenic ulcer after the treatment of argon plasma coagulation,endoscopic mucosal resection and endoscopic submucosal dissection, let them take Jianweiyuyang pills and Rabeprazole capsules to make a clinical control treatment. Then drug efficacy were observed.Result：Two groups of patients during treatment did not be found complications such as gastric antrum mucosa hemorrhage, perforation. In Jianweiyuyang pills group, after 1 month of the last treatment review, there were 48 cases （90.6%） showed red ulcer scars （S1 period）. After 3 month of the surgery review,there were 52 cases （98.1%） showed white ulcer scars （S1 period）. EUS appears as Sc of 50 cases （94.3%） after 6 month of the surgery.In Rabeprazole capsules group, after 1 month of the last treatment review,there were 47 cases （94.0%） showed red ulcer scars （S1 period）. After 3 month of the surgery review, there were 45 cases （90.0%） showed white ulcer scars （S1 period）. EUS appears as Sc of 40 cases （80.0%）after 6 month of the surgery.The quality of ulcer healing of Jianweiyuyang pills group with stage Sc was better than Rabeprazole capsules group, the difference was statistically significant （P〈0.05）. Conclusion：Short-term efficacy is quite of treating the Iatrogenic ulcer by taking Jianweiyuyang pills or Rabeprazole capsules. Long-term effects （the Sc period of ulcer healing quality） of taking Jianweiyuyang pills is better than Rabeprazole capsules . The author believes that Jianweiyuyang pills is an ideal drug for treating the artificial ulcer, and can be a selection for clinical application.