血液透析滤过与血液透析串联血液灌流治疗尿毒症患者的临床价值研究

The Value Research of Hemodialysis Filtration and Hemodialysis Series Blood Perfusion in the Treatment of Uremia Patients

目的:探讨血液透析串联血液灌流治疗尿毒症的临床效果,总结其临床应用价值。方法:选取2012年6月-2014年6月本院收治的尿毒症患者40例,按双盲法将其分成试验组20例,对照组20例,对照组病例接受血液透析治疗,试验组病例接受血液透析串联血液灌流治疗,治疗4周后,比较临床效果。结果:与对照组相比,试验组尿毒症患者的治疗效果更佳,治疗后试验组PTH(甲状旁腺激素)、β2-MG(β2-微球蛋白)水平分别为(231.6±63.8)ng/L、(4.3±1.8)μg/m L,均低于对照组,此外,试验组睡眠、食欲及皮肤瘙痒改善情况优于对照组,两组比较差异均有统计学意义(P<0.05)。结论:血液透析串联血液灌流治疗尿毒症患者的效果优于血液透析滤过,串联治疗法值得进一步应用、推广。

Objective：To discuss the clinical effect of hemodialysis series blood perfusion in the treatment of uremia,summarized the clinical application value.Method： 40 cases of patients with uremia were selected in our hospital from June 2012 to June 2014,according to the double blind method,divided into the experimental group and control group,20 cases in each group.The control group were treated with hemodialysis,the experimental group were treated with hemodialysis series blood perfusion, 4 weeks after treatment,the clinical effect were compared.Result： Compared with the control group, experimental group had better effect to the treatment of patients with uremia, the experimental group after treatment of PTH （parathyroid hormone）,and β2-MG （β2-microglobulin） level were respectively（231.6±63.8） ng/L、（4.3±1.8）ug/mL,lower than the control group,the difference was statistically significant（P〈0.05）.In addition,the experimental group sleep,appetite and itchy skin to improved situation were better than that of control group, the difference was statistically significant（P〈0.05）.Conclusion： Hemodialysis series blood perfusion for the treatment of patients with uremia is better than that of hemodialysis filtration, tandem therapy is worth further application and popularization.