安胃汤治疗慢性萎缩性胃炎疗效与安全性观察

Observation of Clinical Efficacy and Safety on treatment of Anwei decoction for chronic atrophic gastritis

目的:观察安胃汤治疗慢性萎缩性胃炎(CAG)的临床疗效、对胃黏膜病理的影响及用药安全性。方法:入选CAG患者100例,随机分为治疗组与对照组各50例,治疗组口服安胃汤免煎颗粒剂(组成:黄连、干姜、制半夏、百合、乌药等,每次1剂,每日1次);对照组口服胃复春片(每次4片,每日3次)治疗,两组疗程均为3个月。结果:在临床总体疗效方面,治疗组总有效率为94.0%,对照组为72.0%,治疗组优于对照组(P<0.05);治疗组在改善患者中医证候疗效、胃黏膜病理情况等方面亦优于对照组(P<0.05);两组均未出现任何不良反应。结论:安胃汤治疗CAG具有良好的临床疗效与安全性,是一种有效的CAG治疗药物,值得深入研究。

Abstract Objective：To observe clinical effects of Anwei Decoction on chronic atrophic gastritis （CAG） and influence on gastric mucosa pathology and safety of the Decoction. Methods ：100 cases of CAG patients were selected and randomly divided into the Treatment Group and the Control Group （50 cases each ）;the Treatment Group was treated with Anwei boil-free Granule （composition： rhizoma coptidis,dried ginger,processed Rhizoma Pinelliae,lily,Lindera aggregate and so on,one dose each time and once per day） and the Control Group with WeifuchurtTablet （four tablets each time and three times per day） following oral administration. The courses of the treatment for both groups lasted 3 months. Results：In terms of overall clinical efficacy,the total effective rate of the treatment group was 94.0%,72.0% in the control group,the treatment group was superior to the control group （P〈 0.05）;The Treatment Group was superior to the control group in terms of effects on TCM （traditional Chinese medicine） syndrome and gastric mucosa pathology （P〈0.05）. Both groups did not appear any adverse reactions. Conclusion ：A nwei Decoction is an effective and safe medicine for CAG treatment. It is worthy of further study.