桂枝茯苓胶囊联合抗生素对慢性盆腔炎患者超敏C反应蛋白、白细胞介素-2及复发率的影响

Research on Effect of CRP,IL-2 and Recurrence Rate for Treating Chronic Pelvic Inflammation Patients with Gui-Zhi-Fu-Ling Capsule and Antibiotics

目的：观察用桂枝茯苓胶囊联合抗生素治疗慢性盆腔炎患者的临床效果,并探讨其对患者超敏C反应蛋白、白细胞介素-2及复发率的影响。方法：选择2012年6月~2014年2月就诊于我院的118例慢性盆腔炎患者为研究对象,随机分为对照组和观察组患者各59例。对照组患者给予静脉滴注甲硝唑及青霉素常规西医抗生素治疗,1次/d;观察组患者则在对照组抗生素治疗的基础上给予桂枝茯苓胶囊内服治疗,3粒/次,3次/d,1w为1个疗程,连续治疗3个疗程。治疗后观察患者下腹部坠胀、疼痛、腰骶部酸痛等症状的缓解情况,统计临床治疗的有效率;治疗前后对患者的痛感采用疼痛视觉模拟评分VAS进行评价,观察痛感的缓解情况;检测2组患者炎性细胞指标C反应蛋白（CRP）、白细胞介素-2（IL-2）、肿瘤坏死因子（TNF-α）的变化情况;治疗后随访半年,统计患者复发率。结果：经治疗后2组患者下腹部坠胀、疼痛、腰骶部酸痛等临床症状均得到缓解,以观察组缓解程度更为明显,观察组的有效率91.5%明显高于对照组的有效率76.3%,差异有统计学意义（P〈0.05）;2组患者经治疗后痛感有所缓解,VAS疼痛评分较治疗前有所降低,以观察组的降低幅度尤为突出,差异有统计学意义（P〈0.05）;两组患者经治疗后炎性细胞指标CRP、IL-2、TNF-α均有所改善,以观察组的变化程度尤为明显,差异有统计学意义（P〈0.05）;随访半年后,对照组患者的复发率23.7%明显高于观察组患者的复发率8.5%,差异性显著（P〈0.05）。结论：桂枝茯苓胶囊联合抗生素能有效缓解慢性盆腔炎患者的痛感,降低患者的炎性细胞水平,有良好的抗炎作用,疗效确切,是中西医结合论治妇科病的有效方式,值得临床广泛推广运用。

Objective： To investigate the clinical efficacy of treating chronic pelvic inflammation patients with Gui-zhi-fu-ling capsule and antibiotics,and explore the effect onthe CRP,IL-2 and recurrence rate. Methods： 118 chronic pelvic inflammation patients were randomly divided into a control group of 59 cases and a observation group of 59 cases from June 2012 to February2014. Patients in the control group were treated with metronidazole and penicillin for intravenous drip,1 time per day; while patients in the observation group were treated with Gui-zhi-fu-ling capsule on the basis of antibiotics foundation treatment,3 grain per time,3times per day,one week for a course,three courses for treatment. We observed the improvement of clinical symptoms,mainly including hypogastriumtenesmus,pain and lumbosacral ache,andcalculated the effective rate of the two groups; We evaluated the pain with VAS,and tested the level of CRP, IL-2 and TNF-α. Six months of follow-up after treatment, we calculated the recurrence rate. Results： The main clinical symptoms of the patients in two groups,such as hypogastriumtenesmus,pain and lumbosacral ache were improved clearly,the degree of change in the observation group was more pronounced,the efficiency for patients in the observation group is 91. 5%,which was higher than that of the control group 76. 3%,the difference is significant（ P 0. 05）; The VAS score went down clearly,the degree of change in the observation group was more pronounced,the difference is significant（ P 0. 05）; The levels of CRP,IL-2 and TNF-αin two groups after treatment were improved compared with before treatment,and the degree of change in the observation group was more pronounced,the difference is significant（ P 0. 05）; The recurrence ratefor patients in the control group is 23. 7%,which was higher than that of the observation group 8. 5%,the difference is significant（ P 0. 05）. Conclusion： Treating chronic pelvic inflammation patients with Gui-Zhi-Fu-Ling capsule and antibioticscan improve the pain symptoms,low the level of inflammatory cells. The therapy has good anti-inflammatory effect and definite curative effect,which is an effective way of combining TCM and western medicine for treating gynecological diseases,is worthy of further research and development.