糖尿病治疗热点靶点研究进展

The research advances for hot targets of diabetes treatment

糖尿病发病率高,危害大,备受关注。近来随着对其发病机制和治疗策略的研究日益深入,一些新的靶点被发现。本文综述了糖尿病治疗比较热点的靶点2013-2014年的研究进展,主要包括二肽基肽酶-4(dipeptide peptidase-4,DPP-4)、钠-葡萄糖共转运蛋白2(sodium-glucose cotransporter 2,SGLT2)、蛋白酪氨酸磷酸酶-1B(protein tyrosine phosphatase-1B,PTP-1B)、葡萄糖激酶(glucokinase,GK)、α-葡萄糖苷酶(α-glucosidase,α-Glu)和糖原合成酶激酶-3β(glycogen synthase kinase-3β,GSK-3β)等,重点突出了各个靶标的研究成果,为后续深入研究和临床应用提供参考。

Diabetes mellitus have great harm and high incidence,which attracts us a lot. With the increasing depth of the study on pathogenesis and treatment strategies of diabetes,some new targets are discovered. This article summarizes the research advances for hot targets of diabetes treatment from 2013 to 2014,mainly includes dipeptidyl peptidase-4（ DPP-4）,sodium-glucose cotransporter 2（ SGLT2）,protein tyrosine phosphatase-1B（ PTP-1B）,glucokinase（ GK）,α-glucosidase（ α-Glu）,glycogen synthase kinase-3β（ GSK-3β） and so on,highlights the research achievements of every target,so as to provide a reference for subsequent researches and clinical applications.