冠心病患者血清胆红素与铁蛋白水平变化及意义

CHANGES AND CLINICAL SIGNIFICANCE OF SERUM BILIRUBIN AND FERRIN IN PATIENTS WITH CORONARY HEART DISEASE

目的 探讨冠心病患者血清胆红素浓度与铁蛋白水平变化及其意义。方法 选取 60例冠心病患者及 50例正常人 ,均采空腹静脉血测定血清胆红素、铁蛋白 (SF)、总抗氧化能力 (T -AOC)、丙二醛 (MDA)及血浆氧化修饰低密度脂蛋白 (Ox -LDL)浓度。结果 与正常人比 ,冠心病患者血清胆红素与T -AOC明显降低 (P均 <0 .0 1 ) ,SF与MDA及Ox -LDL明显升高 (P均 <0 .0 1 ) ,经直线相关分析 ,血清总胆红素浓度与T -AOC呈正相关 (r =0 .377,P <0 .0 1 ) ,与MDA和Ox -LDL呈负相关 (r =- 0 .31 6和 - 0 .342 ,P <0 .0 5和 0 .0 1 )。SF与MDA和Ox -LDL均呈正相关 (r =0 .2 1 4和 0 .2 38,P均 <0 .0 5)。结论 冠心病患者血清胆红素浓度明显降低并铁储存水平明显升高 。

Objective To explore the changes and the clinical significance of serum bilirubin and ferrin in patients with coronary heart disease (CHD). Methods Serum bilirubin (SB), serum ferrin (SF), total antioxidative capacity (T-AOC), malondiadehyde (MDA) and oxidatively modified lipoprotein (Ox-LDL) were measured in 60 patients of CHD and 50 normal subjects as control group. Results CHD group showed significant lower SB, T-AOC (P<0.01) and significant higher SF, MDAM, Ox-LDL (P<0.01) compared with the control group. On linear correlation analysis, serum total bilirubin concentration was positively correlated with T-AOC (r=0.377, P<0.05) and inversely correlated with MDA (r=0.316, P<0.05) and Ox-LDL (r=0.342,P<0.01). SF was slightly correlated with MDA (r=0.214, P<0.05) and Ox-LDL (r=0.238, P<0.05). Conclusion That the lower serum bilirubin concentration inhibit T-AOC and iron overload promote lipid peroxidation may play an important role in the atherogenic process.