兰州市2378例腹泻婴幼儿A群轮状病毒感染情况调查

Investigation of group A human rotavirus infection situation in 2378 infantile and young children cases of diarrhea

目的调查分析该市腹泻婴幼儿A群轮状病毒感染情况,同时观察患儿的性别、年龄与病毒阳性率的关系。方法收集该院2013年1～12月腹泻婴幼儿粪便标本2 378例,采用免疫层析夹心法检测标本内的A群轮状病毒抗原,分析A群轮状病毒不同月份感染阳性率,并与细菌性腹泻比较;分析患儿不同性别、年龄的病毒阳性率及其差异性。结果该市腹泻婴幼儿粪便中A群轮状病毒阳性率合计为24.1%,以10～12月最高（39.8%）;细菌性腹泻阳性率合计为28.2%,以7～9月最高（38.2%）。男患儿A群轮状病毒阳性率为25.5%,女患儿A群轮状病毒阳性率为22.6%,差异无统计学意义（P〉0.05）。患儿不同年龄间A群轮状病毒阳性率比较差异有统计学意义（P〈0.05）。其中小于2岁患儿平均阳性率最高（29.0%）,其次为2～〈4岁患儿平均阳性率（21.8%）。结论腹泻婴幼儿A群轮状病毒在冬季和初春季节感染阳性率较高,且主要集中小于2岁的患儿。

Objective To investigate the infection situation of group A human rotavirus（HRV）among the infants and young children with diarrhea in Lanzhou city,and to observe the relation between genders and age with the viral positive rate.Methods2 378 samples of feces in the infants and young children with diarrhea were collected in this hospital from January to December^2013.The group A HRV antigen in samples was detected by using the immunochromatographic sandwich method.The positive rates of group A HRV infection in different months were analyzed and compared with the bacterial diarrhea;the viral positive rates in different genders and ages were analyzed.Results Among 2 378 detected feces samples,the average positive rate of group A HRV was 24.1% and the highest was 39.8% during the months from October to December;the average positive rate of bacterial diarrhea was 28.2%and the highest was 38.2% during the months from July to September.The positive rate of group A HRV was25.5%in male children patients and 22.6%in female children patients,but the difference was not statistically significant（P〉0.05）.The differences in the positive rates of group A HRV among different ages had statistical significance（P〈0.05）.The average positive rate was highest（29.0%）in children patients aged less than 2years old,followed by the children patients aged 2- 4〈years old,which was 21.6%.Conclusion The group A HRV has the higher infection positive rate in winter and early spring,which mainly focuses on the children patients aged less than 2years old.