新生儿上消化道出血应用血凝酶的效果研究

Curative effect of blood coagulation enzyme on neonatal upper gastrointestinal hemorrhage

目的研究新生儿上消化道出血应用血凝酶的效果与出凝血功能的关系。方法选取2011年3月至2013年3月海南省文昌市庆龄妇幼保健院新生儿科病房收治的100例上消化道出血患儿,依据随机数字表法将这些患儿分为观察组和对照组,每组50例。给予对照组患儿常规治疗,给予观察组患儿常规治疗基础上加血凝酶治疗。结果两组中凝血功能正常患者的止血时间、治疗总有效率和病理性黄疸、电解质紊乱、糖代谢紊乱等并发症发生率之间的差异均无显著性差异(t=4.303;x^2值分别为11.07、7.38、9.35、11.14,均P>0.05),但观察组中凝血功能异常患者治疗的总有效率高于对照组(x^2=16.92,P<0.05),止血时间比对照组短(t=3.182,P<0.05),病理性黄疸发生率比对照组低(x=18.31,P<0.05)。结论出凝血功能异常的新生儿上消化道出血应用血凝酶的效果显著。

Objective To study the relationship between the effect of blood coagulation enzyme on neonatal upper gastrointestinal hemorrhage and coagulation function. Methods From March 2011 to March 2013 totally 100 neonates with upper gastrointestinal hemorrhage admitted in the neonatal ward of Qingling Maternal and Child Care Service Centre were selected, and they were divided into observation group and control group according to a random number table with 50 cases in each group. The control group was given conventional treatment, while the observation group was provided with blood coagulation enzyme on the basis of conventional treatment. Results There were no significant differences in hemostasis time and total effective rate among patients with normal coagulation between two groups, and the differences in incidence of complications such as pathological jaundice, electrolyte disturbances and glycometabolism disorder were also significant （t = 4. 303 ; χ^2 value was 11.07, 7.38, 9.35 and 11.14, respectively, all P 〉 0.05 ）. However, in the observation group the total effective rate of patients with abnormal coagnlation function was significantly higher （χ^2 = 16.92, P 〈 0.05 ）, hemostasis time was shorter （t = 3. 182 ,P 〈 0.05） and the incidence of pathological jaundice was lower （χ^2 = 18.31 ,P 〈 0.05） than that in the control group. Conclusion The effect of blood coagulation enzyme is significant in the treatment of neonatal upper gastrointestinal hemorrhage with abnormal coagulation function.