子宫内膜异位患者细胞因子及CA125水平分析

Serum cytokines and CA125 level in endometriosis patients

目的探讨子宫内膜异位症患者血清细胞因子中抗子宫内膜抗体(EMAb)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)及糖类抗原CA125(CA125)水平的表达及临床意义。方法选取2013年1至6月顺义中医医院收治的50例子宫内膜异位症患者,分为轻症组和重症组两组,每组25例;将轻症组和重症组患者作为观察组,另选取同期正常健康体检的妇女50例作为对照组。对两组患者的血清细胞因子与CA125水平进行测定。结果观察组患者的EMAb阳性检出率显著高于对照组(x^2=2.776,P<0.05);观察组患者的血清TNF-α、IL-8和CA125水平显著高于对照组(t值分别为3.578、4.116、3.895,均P<0.05);重症组患者的TNF-α、IL-8和CA125水平均显著高于轻症组(t值分别为2.789、3.554、2.698,均P<0.05)。结论检测血清细胞因子与CA125水平表达对子宫内膜异位症患者具有一定的临床诊断意义,联合检测效果更佳。

Objective To investigate the expression and clinical significance of serum endometrial anti-cytokine antibodies （EMAb）, tumor necrosis faetor-α （TNF-α）, interleukin-8 （IL-8） and carbohydrate antigen CA125 （CA125） levels of endometriosis patients. Methods Fifty cases of endometriosis in Beijing Shunyi District Shunyi Chinese Medicine Hospital were selected from January to June 2013, and they were divided into mild symptom group and severe symptom group with 25 cases in each group. These two groups were regarded as observation group, and another 50 cases of healthy people in the same period were selected in control group. Then eytokines and serum CA125 of two groups were determined. Results The EMAb positive detection rate of the observation group was significantly higher than that of the control group （χ^2 = 2. 776 ,P 〈 0.05 ）. The serum TNF-α, IL-8 and CA125 levels of the observation group were significantly higher than those of the control group （t value was 3. 578, 4. 116 and 3. 895, respectively, all P 〈0.05）. The TNF-α, IL-8 and CA125 levels of severe symptom group were significantly higher than those of mild symptom group （ t value was 2. 789, 3. 554 and 2. 698, respectively, all P 〈 0. 05 ）. Conclusion Detecting serum eytokines expression and CA125 levels has certain significance in the clinical diagnosis of endometriosis patients, and joint detection is better.