胎儿生长受限对物质代谢影响的动物模型研究

Impact of fetal growth restriction on metabolism in animal models

胎儿生长受限(FGR)在人类中的发病率约为8%,其为导致围产期婴儿发病和新生儿死亡的重要原因之一,且与成年期多种疾病相关。多种动物模型已运用于FGR机制的研究。在FGR动物模型中观察到胃肠道结构和功能的改变,消化液分泌下降,肠道有效吸收率降低。这种变化与胃肠道细胞的基因表达改变有关;同时还可观察到多种代谢关键酶的活性改变。这些结构和功能的改变最终影响FGR动物的消化吸收和物质代谢,并与多种疾病相关。该文主要针对不同种动物FGR的模型研究进行了分析。

Around the world almost 8% of human pregnancies are diagnosed as fetal growth restriction （FGR）. FGR is one of the important causes of perinatal morbidity and mortality, and is also associated with metabolic diseases in adulthood. A variety of animal models have been used in the research of FGR. Studies on animal models have shown changes in gut structure and function in FGR individuals, which lead to decline of the secretion of digestive juice and low rate of intestinal absorption. These changes are correlated with the change of gene expression. Moreover, activities of main enzymes are decreased in FGR individuals. These changes in structure and function ultimately affect the digestion, absorption and the metabolism of FGR animals, and they are also related with some diseases. In this paper, different kinds of FGR animal models were analyzed.