XRCC1 Arg399Gln位点多态性与乳腺癌易感性的Meta分析

Meta-Analysis on Relationship between XRCC1 Arg399Gln Polymorphism and Breast Cancer Susceptibility

[目的]评估x射线交叉互补修复基因1（X—ray repair cross complementing proteinl，XRCC1）基因Arg399GIn位点单核苷酸多态性与高加索及亚洲人群乳腺癌（breast cancer，BC）易感性的关系。[方法]检索PubMed、Embase、中国期刊全文数据库（CNKI）、万方数据库、中国生物医学文献数据库（CBM）和中文科技期刊全文数据库（VIP）等数据库，获取有关XRCC1 Arg399Gln位点多态性与高加索及亚洲人群乳腺癌易感性关系的病例对照研究的资料，以病例组及对照组XRCClArg399Gln等位基因分布的比值比（OR）为效应指标，应用Meta分析软件Review Manager（version5．0．10）对各研究原始数据进行统计处理及异质性检验，计算合并OR值及其95％可信区间。[结果]共纳入24项病例对照研究，包括1515l例乳腺癌患者和17179例对照。Meta分析结果显示．XRCClArg399Gln位点Gln／Gln突变型可能会增加亚洲人群乳腺癌的发病风险[Gln／Gin VS．Arg／Arg亚洲组：OR=1．20（95％CI：1．03—1．39），P=0．02；Gln／Gln VS．Arg／Arg＋Arg／Gln亚洲组：OR=1．20（95％CI：1．04～1．38），P=0．01。Gln／Gln VS．Arg／Arg 0R=1．01（95％CI：0．94~1．09），Z=0．35，P0R=0．73；Gln／Gln＋Arg／Gln VS．Arg／Arg OR=1．02（95％CI：0．95-1．09，Z=0．58，P0R=0．56；Gln／Gln VS．Arg／Arg＋Arg／Gln OR=1．01（95％CI：0．95～1．08），Z=0．33，P0R-0．74）．[结论]XRCCl Arg399Gln 位点Gln/Gln突变型可能与亚洲人群乳腺癌易感性相关。

[Purpose] To investigate the relationship between X-ray repair cross-complementing group 1 （XRCC l） Arg399Gln polymorphism and breast cancer susceptibility in Caucasians and Asians by meta-analysis. [MethodsJ The data of cast-control studies on the association between XRCC1 Arg399Gln polymorphism and breast cancer susceptibility of Caucasians and Asians in PuhMed, Embase,CBM,VIP,CNKI and Wanfang database were enrolled. Odds ratio （OR） of XRCC1 Arg399Gln genotype distributions in patients with breast cancer and healthy controls was calculat- ed and treated as effective variable ,by which the relationship between XRCC1 Arg399Gln poly- morphism and breast cancer was evaluated. Heterogeneity test and meta-analysis were performed among the included literatures ,and data were analyzed statistically by Review Manager（version 5.0.10） software. [Results] A total of 24 case-control studies were selected including 15151 cases and 17179 controls. Meta-analysis showed that XRCC1 Arg399Gln significantly increased breast cancer risk in Asians （Gin/Gin vs. Arg/Arg in Asians ： OR=1.20 （95%CI ： 1.03~1.39）, P=0.02; Gln/ Gln vs. Arg/Arg ＋Arg/Gln in Asians：OR=1.20 （95%CI： 1.04~1.38）,P=0.01 o Gln/Gln vs. Arg/Arg OR=1.01 （95%CI：0.94-1.09）,Z=0.35,PoR=0.73;Gln/Gln＋Arg/Gln vs. Arg/Arg OR=1.02 （95%CI ： 0.95-1.09）, Z=0.58, POR=0.56 ; Gln/Gln vs. Arg/Arg＋Arg/Gln OR= 1.01 （95%CI ： 0.95-1.08）, Z=0.33, POR=0.74. [ Conclusion ] The XRCC 1 Arg399Gln polymorphism might relate to breast cancer sus- ceptibility in Asians.