乳腺癌改良根治术联合化疗对患者并发症与生活质量的影响

Effects of modified radical mastectomy combined with chemotherapy on complications and quality of life in patients with breast cancer

目的：探讨改良根治术联合化疗对乳腺癌患者术后并发症以及生活质量的影响。方法回顾性分析175例早期乳腺癌患者的临床资料，根据手术治疗方式的不同，分为对照组（n ＝100）和研究组（n ＝75），研究组行改良根治术，术前、术后联合化疗辅助治疗，对照组采用传统的标准根治手术，随访1～3年，比较两组复发、死亡情况以及术后并发症、生活质量的差异性。结果研究组 3年随访局部及腋淋巴结复发率分别为6．7％、2．7％，远处转移率为10．7％，3年生存率为92％，与对照组比较（6％、3％、11％、91％），差异无统计学意义（P ＞0．05）；研究组术后并发症的发生率（6．7％）明显低于对照组（42％），差异有统计学意义（P ＜0．05）；并且术后生活质量大大提高，各项评分明显优于对照组（P ＜0．05）。结论改良根治术联合化疗对于早期乳腺癌的临床治疗疗效与乳腺癌标准根治术相当，而在减少并发症、提高患者术后生活质量方面优势明显。

Objective To explore the effects of modified radical surgery combined with chemo-therapy on postoperative complications and quality of life in breast cancer patients.Methods The clinical data of 175 patients with early breast cancer were retrospective analyzed.According to the different ways of surgical treatment,patients were divided into the control group（n =100）and the study group（n =75）.In the study group,patients received modified radical mastectomy,and preoperative and postoperative chemo-therapy as adjuvant therapy.In the control group,patients received traditional standard radical surgery.The follow-up ranged from 1 to 3 years.Recurrence,mortality,postoperative complications,and quality of life were compared between the two groups.Results There were no significant differences in local recurrence （6.7% vs 6%）and axillary lymph node recurrence （2.7% vs 3%）,distant metastasis （10.7% vs 11%）,and 5-year survival rate（92% vs 91%）between the study group and control group（P ＆gt;0.05）.In the study group,the incidence of postoperative complications was significantly lower（6.7% vs 42%）, while its score on quality of life significantly improved（P ＆lt;0.05）.Conclusion For early breast cancer, modified radical mastectomy combined with chemotherapy has similar effects as the standard radical mas-tectomy.It has obvious advantages in reducing complications and improving the quality of life,which is worthy of being spread clinically.