儿童肺炎支原体肺炎发病危险因素病例对照研究

Case-control study on risk factors of children pneumonia infected by mycoplasma pneumomiae

目的：探讨儿童肺炎支原体肺炎（ MPP）发病的危险因素，为临床防治MPP提供依据。方法采用病例对照的研究方法，回顾性收集105例MPP病例和149例非MPP病例的资料，采用单因素和多因素logistic回归法筛选影响MPP发病的危险因素。结果单因素logistic回归分析结果显示年龄、反复呼吸道感染、特应性体质、不良生活环境、咯血、血沉升高、白细胞升高、IgM阳性、结节影、磨玻璃样影、斑片状实变影、树芽征等可能为MPP发病的危险因素。多因素logistic回归分析结果显示，年龄（OR=1.486）、反复呼吸道感染（OR=3.337）、IgM阳性（OR=2.524）、结节影（OR=3.673）、磨玻璃样影（OR=3.232）、树芽征（OR=8.199）等均为MPP发病的危险因素。结论年龄、反复呼吸道感染史、IgM阳性、早期X影像学异常结果等均为MPP发生的独立危险因素，应针对这些危险因素提出相应干预措施。

Objective To explore the risk factors of children pneumonia infected by mycoplasma pneumoniae （ MPP） , and to provide basis for preventing and treating MPP. Methods With case-control study method, we retrospectively collected data of 105 cases of MPP and 149 cases of non-MPP, and then used single factor and multiple factors logistic regression analysis methods to screen influencing factors of MPP. Results Single factor logistic regression results indicated that age, repeated respiratory infection, atopic constitution, bad living environment, hemoptysis, elevated ESR, the increase of white blood cell, positive IgM antibody, tubercle shadow, ground-glass shadow, patchy shadow and tree-in-bud pulmonary were the possible risk factors of MPP. Multiple factors logistic regression result showed that age （OR=1. 486）, repeated respiratory infection （OR=3. 337）, positive IgM antibody （OR=2. 524）, tubercle shadow （OR=3. 673, ground-glass shadow （OR=3. 232） and tree-in-bud pulmonary （OR=8. 199） were risk factors of MPP. Conclusion The independent risk factors of MPP include age, repeated respiratory infection, positive IgM antibody and preternatural result of early X imageology. So we should take corresponding intervention measures to aim directly at these risk factors.