平均血小板体积在卵巢上皮癌早期诊断中的应用

The Value of Mean Platelet Volume in Early Diagnosis of Epithelial Ovarian Cancer

目的：探讨平均血小板体积（mean platelet volume, MPV）作为卵巢上皮癌早期诊断指标的应用价值。方法86例行根治术的卵巢上皮癌患者，回顾术前、术后2周血常规检测结果，同时招募86名年龄匹配的健康志愿者作为对照纳入研究。分析卵巢上皮癌患者MPV水平与临床病理特征的相关性；卵巢上皮癌患者术前与术后MPV水平的差异；以及卵巢上皮癌患者术前、术后的MPV水平，与健康志愿者的差异。结果卵巢上皮癌患者MPV水平与年龄、肿瘤分期、病理类型均无明显相关性（P＞0.05）；卵巢上皮癌患者术前MPV水平与对照组差异有统计学意义（8.38±0.47 fL vs.7.61±0.53 fL；P＜0.01）；卵巢上皮癌患者术前与术后的MPV水平差异有统计学意义（8.38±0.47 fL vs.7.58±0.67 fL；P＜0.01）；卵巢上皮癌患者术后MPV水平与对照组差异无统计学意义（7.58±0.67 fL vs.7.61±0.53 fL；P=0.233）。结论MPV有可能应用于卵巢上皮癌高危人群的早期诊断。

Objective To investigate the application of mean platelet volume （MPV） in the early diagnosis of epithelial ovarian cancer. Methods 86 epithelial ovarian cancer patients who received radical resection and 86 age-matched healthy subjects were enrolled in this study. MPV level of epithelial ovarian cancer patient was tested pre-operation and 2 weeks after operation. MPV levels were compared between pre-and post-operative samples. The pre-and post-operative MPV levels were also compared with the MPV level obtained from healthy subjects respectively. Results MPV level of epithelial ovarian cancer patients had no association with age, stages or pathological types （P〉0.05）. MPV level was significantly higher in pre-operative epithelial ovarian cancer patients compared to healthy subjects （8.38±0.47 fL vs. 7.61±0.53 fL; P〈0.01）. The MPV level decreased significantly 2 weeks after operation （8.38±0.47 fL vs. 7.58±0.67 fL; P〈0.01）. There was no significant difference in MPV levels of post-operative patients and healthy subjects （7.58±0.67 fL vs. 7.61±0.53 fL;P=0.233）. Conclusion Changes in MPV values may be used as an easily available biomarker for monitoring the healthy patients bearing epithelial ovarian cancer risks and may contribute to the early diagnosis of epithelial ovarian cancer.