CyclinD1和Survivin在腮腺肿瘤中的表达

CyclinD1 and Survivin expression in parotid gland tumors

目的探究细胞周期蛋白（CyclinD1）和凋亡抑制因子（Survivin）在腮腺肿瘤中的表达关系。方法选取自2012年10月19日～2014年7月19日来我院进行治疗的54例腮腺肿瘤患者的病理切片。结果CyclinD1在常人组、良性肿瘤组和恶性肿瘤组的阳性率分别为5．0％、25．0％和70．6％，表现明显增高，差异有统计学意义（P〈0．05），Survivin在常人组、良性肿瘤组和恶性肿瘤组的阳性率分别为0．0％、30．0％和67．6％，表达明显增高，差异有统计学意义（尸〈0．05）。结论CyclinD1与Survivin在腮腺肿瘤的发展中起到了协同作用，可作为腮腺诊治的重要参考依据。

Objective To explore the cell cycle protein （CyclinD1） and apoptosis inhibiting factor （Survivin） expression in parotid gland tumors in the relationship. Methods Select from October 19, 2012 to 2012 on July 19 days the hospital for treatment of 54 patients with parotid g/and tumor pathological section. Results CyclinD1 in the normal group, benign tumor and malignant tumor group, the positive rate of 5.0%, 25.0% and 70.6%, respectively, expression increased obviously, the difference was statistically significant （P〈0.05）, Survivin in the normal group, benign tumor and malignant tumor group were 0.0%, 30.0% and 67.6%, respectively, to express obviously increased, the difference was statistically significant （P〈0.05）. Conclusion CyclinD1 and Survivin in parotid gland tumor development played a synergy, can be used as important reference for diagnosis and treatment ofparotid gland.