广东紫珠乙酸乙酯部位化学成分研究

Ethyl Acetate-soluble Chemical Constituents from Callicarpa kwangtungensis

目的:研究广东紫珠Callicarpa kwangtungensis Chun乙酸乙酯部位的化学成分。方法:利用硅胶、Sephadex LH-20、MPLC等色谱方法进行分离纯化,根据理化性质、波谱方法进行结构鉴定。结果:从广东紫珠乙酸乙酯部位分离得到7个化合物,分别鉴定为:咖啡酸(1)、2α,3α,19α-三羟基乌苏烷-12-烯-28-O-β-D-吡喃葡萄糖苷(2)、2α,3β,19α-三羟基齐墩果烷-12-烯-28-O-β-D-吡喃葡萄糖苷(3)、2α,3α,19α-三羟基齐墩果烷-12-烯-28-O-β-D-吡喃葡萄糖苷(4)、阿魏酸(5)、2α,3β,19α-三羟基乌苏烷-12-烯-28-O-β-D-吡喃葡萄糖苷(6)、(+)-异落叶松脂素-9-O-β-D-吡喃葡萄糖苷(7)。结论:以上化合物均为首次从该植物中分离得到。

Objective： To study the ethyl acetate-soluble chemical constituents of Callicarpa kwangtungensis. Methods： The chemical constituents were isolated by column chromatography on silica gel,Sephadex LH-20 and MPLC. Their chemical structures were elucidated on the basis of special analysis. Results： Seven compounds were isolated from ethyl acetate part,whose structures were elucidated as caffeic acid（ 1）,2α,3α,19α-trihyhydroxy-urs-12-en-28-O-β-D-glucopyranoside（ 2）,2α,3β,19α-trihyhydroxy-olean-12-en-28-O-β-D-glucopyranoside（ 3）,2α,3α,19α-trihyhydroxy-olean-12-en-28-O-β-D-glucopyranoside（ 4）,ferulic acid（ 5）,2α,3β,19α-trihyhydroxy-urs-12-en-28-O-β-D-glucopyranoside（ 6）,and（ ＋）-isolariciresinol-9-O-β-D-glucopyranoside（ 7）. Conclusion： All these compounds are isolated from this plant for the first time.